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HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T. Ferretti GDS, et al. Cell Death Differ. 2024 Jul;31(7):881-896. doi: 10.1038/s41418-024-01310-9. Epub 2024 May 28. Cell Death Differ. 2024. PMID: 38802657 Free PMC article.
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer.
Saatci O, Alam R, Huynh-Dam KT, Isik A, Uner M, Belder N, Ersan PG, Cetin M, Tokat UM, Gedik ME, Bal H, Sahin OS, Riazalhosseini Y, Thieffry D, Gautheret D, Ogretmen B, Aksoy S, Uner A, Akyol A, Sahin O. Saatci O, et al. bioRxiv [Preprint]. 2023 Nov 5:2023.11.05.565697. doi: 10.1101/2023.11.05.565697. bioRxiv. 2023. Update in: Cell Death Dis. 2024 Jun 15;15(6):418. doi: 10.1038/s41419-024-06814-3 PMID: 38496603 Free PMC article. Updated. Preprint.
A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer.
Cetin M, Saatci O, Rezaeian AH, Rao CN, Beneker C, Sreenivas K, Taylor H, Pederson B, Chatzistamou I, Buckley B, Lessner S, Angel P, McInnes C, Sahin O. Cetin M, et al. Cell Chem Biol. 2024 Nov 21;31(11):1926-1941.e11. doi: 10.1016/j.chembiol.2024.06.012. Epub 2024 Jul 22. Cell Chem Biol. 2024. PMID: 39043186 Free article.