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Leptin does not directly affect CNS serotonin neurons to influence appetite.
Lam DD, Leinninger GM, Louis GW, Garfield AS, Marston OJ, Leshan RL, Scheller EL, Christensen L, Donato J Jr, Xia J, Evans ML, Elias C, Dalley JW, Burdakov DI, Myers MG Jr, Heisler LK. Lam DD, et al. Cell Metab. 2011 May 4;13(5):584-91. doi: 10.1016/j.cmet.2011.03.016. Cell Metab. 2011. PMID: 21531340 Free PMC article.