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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Yan R, et al. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. Cell Stem Cell. 2023. PMID: 36516837 Free PMC article.
An injury-responsive mmp14b enhancer is required for heart regeneration.
Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL. Zlatanova I, et al. Sci Adv. 2023 Dec;9(48):eadh5313. doi: 10.1126/sciadv.adh5313. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019918 Free PMC article.
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. Smith GA, et al. Sci Transl Med. 2022 Sep 14;14(662):eabj8670. doi: 10.1126/scitranslmed.abj8670. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103516 Free PMC article.
Control of ribosomal protein synthesis by the Microprocessor complex.
Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Jiang X, et al. Sci Signal. 2021 Feb 23;14(671):eabd2639. doi: 10.1126/scisignal.abd2639. Sci Signal. 2021. PMID: 33622983 Free PMC article.