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Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.
Grenier-Larouche T, Coulter Kwee L, Deleye Y, Leon-Mimila P, Walejko JM, McGarrah RW, Marceau S, Trahan S, Racine C, Carpentier AC, Lusis AJ, Ilkayeva O, Vohl MC, Huertas-Vazquez A, Tchernof A, Shah SH, Newgard CB, White PJ. Grenier-Larouche T, et al. JCI Insight. 2022 Aug 8;7(15):e159204. doi: 10.1172/jci.insight.159204. JCI Insight. 2022. PMID: 35797133 Free PMC article.
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.
Guilherme A, Rowland LA, Wetoska N, Tsagkaraki E, Santos KB, Bedard AH, Henriques F, Kelly M, Munroe S, Pedersen DJ, Ilkayeva OR, Koves TR, Tauer L, Pan M, Han X, Kim JK, Newgard CB, Muoio DM, Czech MP. Guilherme A, et al. Cell Rep. 2023 May 30;42(5):112488. doi: 10.1016/j.celrep.2023.112488. Epub 2023 May 8. Cell Rep. 2023. PMID: 37163372 Free PMC article.
The intestine is a major contributor to circulating succinate in mice.
Tong W, Hannou SA, Wang Y, Astapova I, Sargsyan A, Monn R, Thiriveedi V, Li D, McCann JR, Rawls JF, Roper J, Zhang GF, Herman MA. Tong W, et al. FASEB J. 2022 Oct;36(10):e22546. doi: 10.1096/fj.202200135RR. FASEB J. 2022. PMID: 36106538 Free PMC article.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, Stevens RD, Koves TR, Muoio DM, Brozinick JT, Gimeno RE, Brosnan MJ, Rolph TP, Kraus WE, Shah SH, Newgard CB. White PJ, et al. Cell Rep. 2020 Nov 10;33(6):108375. doi: 10.1016/j.celrep.2020.108375. Cell Rep. 2020. PMID: 33176135 Free PMC article.
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA. Sargsyan A, et al. JCI Insight. 2023 Jan 10;8(1):e153740. doi: 10.1172/jci.insight.153740. JCI Insight. 2023. PMID: 36413406 Free PMC article.
Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.
Yenilmez B, Kelly M, Zhang GF, Wetoska N, Ilkayeva OR, Min K, Rowland L, DiMarzio C, He W, Raymond N, Lifshitz L, Pan M, Han X, Xie J, Friedline RH, Kim JK, Gao G, Herman MA, Newgard CB, Czech MP. Yenilmez B, et al. J Biol Chem. 2022 Oct;298(10):102401. doi: 10.1016/j.jbc.2022.102401. Epub 2022 Aug 18. J Biol Chem. 2022. PMID: 35988648 Free PMC article.
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