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Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer.
Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. Maguire OA, et al. Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018. Epub 2021 Feb 16. Cell Metab. 2021. PMID: 33596409 Free PMC article.
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Gobert AP, Smith TM, Latour YL, Asim M, Barry DP, Allaman MM, Williams KJ, McNamara KM, Delgado AG, Short SP, Mirmira RG, Rose KL, Schey KL, Zagol-Ikapitte I, Coleman JS, Boutaud O, Zhao S, Piazuelo MB, Washington MK, Coburn LA, Wilson KT. Gobert AP, et al. Gastroenterology. 2023 Sep;165(3):656-669.e8. doi: 10.1053/j.gastro.2023.05.041. Epub 2023 Jun 2. Gastroenterology. 2023. PMID: 37271289 Free PMC article.
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Sims EK, Kulkarni A, Hull A, Woerner SE, Cabrera S, Mastrandrea LD, Hammoud B, Sarkar S, Nakayasu ES, Mastracci TL, Perkins SM, Ouyang F, Webb-Robertson BJ, Enriquez JR, Tersey SA, Evans-Molina C, Long SA, Blanchfield L, Gerner EW, Mirmira RG, DiMeglio LA. Sims EK, et al. Cell Rep Med. 2023 Nov 21;4(11):101261. doi: 10.1016/j.xcrm.2023.101261. Epub 2023 Nov 1. Cell Rep Med. 2023. PMID: 37918404 Free PMC article. Clinical Trial.
Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A.
Gonzalez-Menendez P, Phadke I, Olive ME, Joly A, Papoin J, Yan H, Galtier J, Platon J, Kang SWS, McGraw KL, Daumur M, Pouzolles M, Kondo T, Boireau S, Paul F, Young DJ, Lamure S, Mirmira RG, Narla A, Cartron G, Dunbar CE, Boyer-Clavel M, Porat-Shliom N, Dardalhon V, Zimmermann VS, Sitbon M, Dever TE, Mohandas N, Da Costa L, Udeshi ND, Blanc L, Kinet S, Taylor N. Gonzalez-Menendez P, et al. Blood. 2023 May 18;141(20):2520-2536. doi: 10.1182/blood.2022017584. Blood. 2023. PMID: 36735910 Free PMC article.
GDF15: a potential therapeutic target for type 1 diabetes.
Sarkar S, Melchior JT, Henry HR, Syed F, Mirmira RG, Nakayasu ES, Metz TO. Sarkar S, et al. Expert Opin Ther Targets. 2022 Jan;26(1):57-67. doi: 10.1080/14728222.2022.2029410. Epub 2022 Feb 9. Expert Opin Ther Targets. 2022. PMID: 35138971 Free PMC article. Review.
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