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Page 1
Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan HÜ, Martini ML, Jin J. Kaniskan HÜ, et al. Chem Rev. 2018 Feb 14;118(3):989-1068. doi: 10.1021/acs.chemrev.6b00801. Epub 2017 Mar 24. Chem Rev. 2018. PMID: 28338320 Free PMC article. Review.
Chemical probes of histone lysine methyltransferases.
Kaniskan HÜ, Jin J. Kaniskan HÜ, et al. ACS Chem Biol. 2015 Jan 16;10(1):40-50. doi: 10.1021/cb500785t. Epub 2014 Nov 25. ACS Chem Biol. 2015. PMID: 25423077 Free PMC article. Review.
Selective inhibitors of protein methyltransferases.
Kaniskan HÜ, Konze KD, Jin J. Kaniskan HÜ, et al. J Med Chem. 2015 Feb 26;58(4):1596-629. doi: 10.1021/jm501234a. Epub 2014 Dec 2. J Med Chem. 2015. PMID: 25406853 Free PMC article.
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.
Xiong Y, Li F, Babault N, Wu H, Dong A, Zeng H, Chen X, Arrowsmith CH, Brown PJ, Liu J, Vedadi M, Jin J. Xiong Y, et al. Bioorg Med Chem. 2017 Aug 15;25(16):4414-4423. doi: 10.1016/j.bmc.2017.06.021. Epub 2017 Jun 19. Bioorg Med Chem. 2017. PMID: 28662962 Free PMC article.
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M. Kaniskan HÜ, et al. Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154. Epub 2015 Feb 27. Angew Chem Int Ed Engl. 2015. PMID: 25728001 Free PMC article.
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM. Lehnertz B, et al. Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794.113. Genes Dev. 2014. PMID: 24532712 Free PMC article.
40 results