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Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.
Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M. Dhanasekaran A, et al. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H724-35. doi: 10.1152/ajpheart.00979.2007. Epub 2007 Nov 30. Am J Physiol Heart Circ Physiol. 2008. PMID: 18055514 Free PMC article.