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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants.
Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Zhang L, et al. Nat Chem Biol. 2022 Mar;18(3):342-351. doi: 10.1038/s41589-021-00965-6. Epub 2022 Jan 19. Nat Chem Biol. 2022. PMID: 35046611 Free PMC article.
Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation.
Skeeters S, Bagale K, Stepanyuk G, Thieker D, Aguhob A, Chan KK, Dutzar B, Shalygin S, Shajahan A, Yang X, DaRosa PA, Frazier E, Sauer MM, Bogatzki L, Byrnes-Blake KA, Song Y, Azadi P, Tarcha E, Zhang L, Procko E. Skeeters S, et al. Mol Ther Methods Clin Dev. 2024 Jul 19;32(3):101301. doi: 10.1016/j.omtm.2024.101301. eCollection 2024 Sep 12. Mol Ther Methods Clin Dev. 2024. PMID: 39185275 Free PMC article.
Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants.
Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Zhang L, et al. bioRxiv [Preprint]. 2021 Dec 22:2021.12.21.473668. doi: 10.1101/2021.12.21.473668. bioRxiv. 2021. Update in: Nat Chem Biol. 2022 Mar;18(3):342-351. doi: 10.1038/s41589-021-00965-6 PMID: 34981059 Free PMC article. Updated. Preprint.
An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.
Zhang L, Narayanan KK, Cooper L, Chan KK, Devlin CA, Aguhob A, Shirley K, Rong L, Rehman J, Malik AB, Procko E. Zhang L, et al. bioRxiv [Preprint]. 2022 Mar 28:2022.03.28.486075. doi: 10.1101/2022.03.28.486075. bioRxiv. 2022. Update in: EMBO Mol Med. 2022 Nov 8;14(11):e16109. doi: 10.15252/emmm.202216109 PMID: 35378764 Free PMC article. Updated. Preprint.