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Page 1
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM. Bailus BJ, et al. Autophagy. 2021 Dec;17(12):4119-4140. doi: 10.1080/15548627.2021.1904489. Epub 2021 May 24. Autophagy. 2021. PMID: 34024231 Free PMC article.
iPSC-based drug screening for Huntington's disease.
Zhang N, Bailus BJ, Ring KL, Ellerby LM. Zhang N, et al. Brain Res. 2016 May 1;1638(Pt A):42-56. doi: 10.1016/j.brainres.2015.09.020. Epub 2015 Sep 30. Brain Res. 2016. PMID: 26428226 Free PMC article. Review.
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Tshilenge KT, Aguirre CG, Bons J, Gerencser AA, Basisty N, Song S, Rose J, Lopez-Ramirez A, Naphade S, Loureiro A, Battistoni E, Milani M, Wehrfritz C, Holtz A, Hetz C, Mooney SD, Schilling B, Ellerby LM. Tshilenge KT, et al. Mol Cell Proteomics. 2023 May;22(5):100534. doi: 10.1016/j.mcpro.2023.100534. Epub 2023 Mar 22. Mol Cell Proteomics. 2023. PMID: 36958627 Free PMC article.
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
Creus-Muncunill J, Haure-Mirande JV, Mattei D, Bons J, Ramirez AV, Hamilton BW, Corwin C, Chowdhury S, Schilling B, Ellerby LM, Ehrlich ME. Creus-Muncunill J, et al. J Neuroinflammation. 2024 Mar 8;21(1):66. doi: 10.1186/s12974-024-03052-4. J Neuroinflammation. 2024. PMID: 38459557 Free PMC article.
28 results