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PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC.
Lechuga CG, Hernández-Nazara ZH, Hernández E, Bustamante M, Desierto G, Cotty A, Dharker N, Choe M, Rojkind M. Lechuga CG, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1051-61. doi: 10.1152/ajpgi.00058.2005. Epub 2006 Sep 21. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16990448 Free article.
TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k.
Lechuga CG, Hernández-Nazara ZH, Domínguez Rosales JA, Morris ER, Rincón AR, Rivas-Estilla AM, Esteban-Gamboa A, Rojkind M. Lechuga CG, et al. Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G974-87. doi: 10.1152/ajpgi.00264.2003. Epub 2004 Jul 8. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 15246963 Free article.