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Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.
J Med Chem. 2012 Aug 9;55(15):6975-9. doi: 10.1021/jm300700v. Epub 2012 Jul 26.
J Med Chem. 2012.
PMID: 22793372
Free PMC article.
Autonomous transmembrane segment S4 of the voltage sensor domain partitions into the lipid membrane.
Tiriveedhi V, Miller M, Butko P, Li M.
Tiriveedhi V, et al.
Biochim Biophys Acta. 2012 Jul;1818(7):1698-705. doi: 10.1016/j.bbamem.2012.03.011.
Biochim Biophys Acta. 2012.
PMID: 22465069
Free PMC article.
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