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2014 | 2 |
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Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19.
J Biol Chem. 2014.
PMID: 25239621
Free PMC article.
Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential?
Wolfe MS.
Wolfe MS.
Future Neurol. 2014;9(4):419-429. doi: 10.2217/fnl.14.35.
Future Neurol. 2014.
PMID: 26146489
Free PMC article.
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Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.
Fernandez MA, Biette KM, Dolios G, Seth D, Wang R, Wolfe MS.
Fernandez MA, et al.
Biochemistry. 2016 Oct 11;55(40):5675-5688. doi: 10.1021/acs.biochem.6b00718. Epub 2016 Sep 30.
Biochemistry. 2016.
PMID: 27649271
Free PMC article.
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