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Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms.
Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503144. doi: 10.1016/j.mrgentox.2020.503144. Epub 2020 Jan 22.
Mutat Res Genet Toxicol Environ Mutagen. 2020.
PMID: 32087851
Free PMC article.
Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.
Bariar B, Vestal CG, Deem B, Goodenow D, Ughetta M, Engledove RW, Sahyouni M, Richardson C.
Bariar B, et al.
Environ Mol Mutagen. 2019 Mar;60(2):154-167. doi: 10.1002/em.22245. Epub 2018 Nov 2.
Environ Mol Mutagen. 2019.
PMID: 30387535
Free PMC article.
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