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APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis.
Wörmann SM, Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MHG, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD. Wörmann SM, et al. Nat Cancer. 2021 Dec;2(12):1338-1356. doi: 10.1038/s43018-021-00268-8. Epub 2021 Nov 18. Nat Cancer. 2021. PMID: 35121902
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
Law EK, Levin-Klein R, Jarvis MC, Kim H, Argyris PP, Carpenter MA, Starrett GJ, Temiz NA, Larson LK, Durfee C, Burns MB, Vogel RI, Stavrou S, Aguilera AN, Wagner S, Largaespada DA, Starr TK, Ross SR, Harris RS. Law EK, et al. J Exp Med. 2020 Dec 7;217(12):e20200261. doi: 10.1084/jem.20200261. J Exp Med. 2020. PMID: 32870257 Free PMC article.