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T cell responses to SARS-CoV-2 spike cross-recognize Omicron.
Keeton R, Tincho MB, Ngomti A, Baguma R, Benede N, Suzuki A, Khan K, Cele S, Bernstein M, Karim F, Madzorera SV, Moyo-Gwete T, Mennen M, Skelem S, Adriaanse M, Mutithu D, Aremu O, Stek C, du Bruyn E, Van Der Mescht MA, de Beer Z, de Villiers TR, Bodenstein A, van den Berg G, Mendes A, Strydom A, Venter M, Giandhari J, Naidoo Y, Pillay S, Tegally H, Grifoni A, Weiskopf D, Sette A, Wilkinson RJ, de Oliveira T, Bekker LG, Gray G, Ueckermann V, Rossouw T, Boswell MT, Bhiman JN, Moore PL, Sigal A, Ntusi NAB, Burgers WA, Riou C. Keeton R, et al. Nature. 2022 Mar;603(7901):488-492. doi: 10.1038/s41586-022-04460-3. Epub 2022 Jan 31. Nature. 2022. PMID: 35102311 Free PMC article.
Impact of SARS-CoV-2 exposure history on the T cell and IgG response.
Keeton R, Tincho MB, Suzuki A, Benede N, Ngomti A, Baguma R, Chauke MV, Mennen M, Skelem S, Adriaanse M, Grifoni A, Weiskopf D, Sette A, Bekker LG, Gray G, Ntusi NAB, Burgers WA, Riou C. Keeton R, et al. Cell Rep Med. 2023 Jan 17;4(1):100898. doi: 10.1016/j.xcrm.2022.100898. Epub 2022 Dec 22. Cell Rep Med. 2023. PMID: 36584684 Free PMC article.
Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis.
Du Bruyn E, Ruzive S, Howlett P, Jacobs AJ, Arlehamn CSL, Sette A, Sher A, Mayer-Barber KD, Barber DL, Mayosi B, Ntsekhe M, Wilkinson RJ, Riou C. Du Bruyn E, et al. Front Immunol. 2022 Nov 11;13:1009016. doi: 10.3389/fimmu.2022.1009016. eCollection 2022. Front Immunol. 2022. PMID: 36439130 Free PMC article.
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity.
Riou C, Keeton R, Moyo-Gwete T, Hermanus T, Kgagudi P, Baguma R, Valley-Omar Z, Smith M, Tegally H, Doolabh D, Iranzadeh A, Tyers L, Mutavhatsindi H, Tincho MB, Benede N, Marais G, Chinhoyi LR, Mennen M, Skelem S, du Bruyn E, Stek C; South African cellular immunity network; de Oliveira T, Williamson C, Moore PL, Wilkinson RJ, Ntusi NAB, Burgers WA. Riou C, et al. Sci Transl Med. 2022 Feb 9;14(631):eabj6824. doi: 10.1126/scitranslmed.abj6824. Epub 2022 Feb 9. Sci Transl Med. 2022. PMID: 34931886 Free PMC article.
Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection.
Riou C, du Bruyn E, Stek C, Daroowala R, Goliath RT, Abrahams F, Said-Hartley Q, Allwood BW, Hsiao NY, Wilkinson KA, Arlehamn CSL, Sette A, Wasserman S, Wilkinson RJ; HIATUS consortium. Riou C, et al. J Clin Invest. 2021 Jun 15;131(12):e149125. doi: 10.1172/JCI149125. J Clin Invest. 2021. PMID: 33945513 Free PMC article. Clinical Trial.
Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.
Benede N, Tincho MB, Walters A, Subbiah V, Ngomti A, Baguma R, Butters C, Hahnle L, Mennen M, Skelem S, Adriaanse M, Facey-Thomas H, Scott C, Day J, Spracklen TF, van Graan S, Balla SR, Moyo-Gwete T, Moore PL, MacGinty R, Botha M, Workman L, Johnson M, Goldblatt D, Zar HJ, Ntusi NAB, Zühlke L, Webb K, Riou C, Burgers WA, Keeton RS. Benede N, et al. iScience. 2023 Dec 14;27(1):108728. doi: 10.1016/j.isci.2023.108728. eCollection 2024 Jan 19. iScience. 2023. PMID: 38235336 Free PMC article.
Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection.
Moyo-Gwete T, Richardson SI, Keeton R, Hermanus T, Spencer H, Manamela NP, Ayres F, Makhado Z, Motlou T, Tincho MB, Benede N, Ngomti A, Baguma R, Chauke MV, Mennen M, Adriaanse M, Skelem S, Goga A, Garrett N, Bekker LG, Gray G, Ntusi NAB, Riou C, Burgers WA, Moore PL. Moyo-Gwete T, et al. medRxiv [Preprint]. 2023 Mar 15:2023.03.15.23287288. doi: 10.1101/2023.03.15.23287288. medRxiv. 2023. Update in: PLoS Pathog. 2023 Nov 9;19(11):e1011772. doi: 10.1371/journal.ppat.1011772 PMID: 36993404 Free PMC article. Updated. Preprint.
16 results