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Engineered antibody fusion proteins for targeted disease therapy.
Silver AB, Leonard EK, Gould JR, Spangler JB. Silver AB, et al. Trends Pharmacol Sci. 2021 Dec;42(12):1064-1081. doi: 10.1016/j.tips.2021.09.009. Epub 2021 Oct 25. Trends Pharmacol Sci. 2021. PMID: 34706833 Free PMC article. Review.
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1.
Ludwig SD, Meksiriporn B, Tan J, Kureshi R, Mishra A, Kaeo KJ, Zhu A, Stavrakis G, Lee SJ, Schodt DJ, Wester MJ, Kumar D, Lidke KA, Cox AL, Dooley HM, Nimmagadda S, Spangler JB. Ludwig SD, et al. Cell Chem Biol. 2024 May 16;31(5):904-919.e11. doi: 10.1016/j.chembiol.2024.02.014. Epub 2024 Mar 27. Cell Chem Biol. 2024. PMID: 38547863
Strategies for Glycoengineering Therapeutic Proteins.
Dammen-Brower K, Epler P, Zhu S, Bernstein ZJ, Stabach PR, Braddock DT, Spangler JB, Yarema KJ. Dammen-Brower K, et al. Front Chem. 2022 Apr 13;10:863118. doi: 10.3389/fchem.2022.863118. eCollection 2022. Front Chem. 2022. PMID: 35494652 Free PMC article. Review.
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1.
Ludwig SD, Meksiriporn B, Tan J, Kureshi R, Mishra A, Kaeo KJ, Zhu A, Stavrakis G, Lee SJ, Schodt DJ, Wester MJ, Kumar D, Lidke KA, Cox AL, Dooley HM, Nimmagadda S, Spangler JB. Ludwig SD, et al. Cell Chem Biol. 2024 May 16;31(5):1023. doi: 10.1016/j.chembiol.2024.04.011. Epub 2024 Apr 27. Cell Chem Biol. 2024. PMID: 38679021 Free PMC article. No abstract available.
Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Hou S, Henclova T, Huliciak M, Sargunas PR, Fabilane CS, Vaněk O, Kovar M, Schneider B, Raimondi G, Leonard WJ, Spangler JB. Leonard EK, et al. JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469. JCI Insight. 2024. PMID: 39115939 Free PMC article.
11 results