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Antidepressants enter cells, organelles, and membranes.
Blumenfeld Z, Bera K, Castrén E, Lester HA. Blumenfeld Z, et al. Neuropsychopharmacology. 2024 Jan;49(1):246-261. doi: 10.1038/s41386-023-01725-x. Epub 2023 Oct 2. Neuropsychopharmacology. 2024. PMID: 37783840 Free PMC article. Review.
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane.
Nichols AL, Blumenfeld Z, Luebbert L, Knox HJ, Muthusamy AK, Marvin JS, Kim CH, Grant SN, Walton DP, Cohen BN, Hammar R, Looger L, Artursson P, Dougherty DA, Lester HA. Nichols AL, et al. J Neurosci. 2023 Mar 29;43(13):2222-2241. doi: 10.1523/JNEUROSCI.1519-22.2022. Epub 2023 Mar 3. J Neurosci. 2023. PMID: 36868853 Free PMC article.
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids.
Haloi N, Huang S, Nichols AL, Fine EJ, Friesenhahn NJ, Marotta CB, Dougherty DA, Lindahl E, Howard RJ, Mayo SL, Lester HA. Haloi N, et al. bioRxiv [Preprint]. 2024 Jan 18:2023.01.16.524298. doi: 10.1101/2023.01.16.524298. bioRxiv. 2024. Update in: Protein Eng Des Sel. 2024 Jan 29;37:gzae003. doi: 10.1093/protein/gzae003 PMID: 36712031 Free PMC article. Updated. Preprint.