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Page 1
The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells.
Copertino DC Jr, Holmberg CS, Weiler J, Ward AR, Howard JN, Levinger C, Pang AP, Corley MJ, Dündar F, Zumbo P, Betel D, Gandhi RT, McMahon DK, Bosch RJ, Linden N, Macatangay BJ, Cyktor JC, Eron JJ, Mellors JW, Kovacs C, Benko E, Bosque A, Jones RB; AIDS Clinical Trials Group (ACTG) A5321 Team. Copertino DC Jr, et al. JCI Insight. 2023 Sep 22;8(18):e169028. doi: 10.1172/jci.insight.169028. JCI Insight. 2023. PMID: 37581929 Free PMC article.
The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2.
Howard JN, Zaikos TD, Levinger C, Rivera E, McMahon EK, Holmberg CS, Terao J, Sanz M, Copertino DC Jr, Wang W, Soriano-Sarabia N, Jones RB, Bosque A. Howard JN, et al. JCI Insight. 2024 Aug 8;9(18):e179680. doi: 10.1172/jci.insight.179680. JCI Insight. 2024. PMID: 39115957 Free PMC article.
The Cultured TCM Model of HIV Latency.
Bosque A. Bosque A. Methods Mol Biol. 2022;2407:45-55. doi: 10.1007/978-1-0716-1871-4_4. Methods Mol Biol. 2022. PMID: 34985656
Fingolimod inhibits multiple stages of the HIV-1 life cycle.
Resop RS, Fromentin R, Newman D, Rigsby H, Dubrovsky L, Bukrinsky M, Chomont N, Bosque A. Resop RS, et al. PLoS Pathog. 2020 Aug 13;16(8):e1008679. doi: 10.1371/journal.ppat.1008679. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32790802 Free PMC article.
Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.
Bosque A, Nilson KA, Macedo AB, Spivak AM, Archin NM, Van Wagoner RM, Martins LJ, Novis CL, Szaniawski MA, Ireland CM, Margolis DM, Price DH, Planelles V. Bosque A, et al. Cell Rep. 2017 Jan 31;18(5):1324-1334. doi: 10.1016/j.celrep.2017.01.022. Cell Rep. 2017. PMID: 28147284 Free PMC article.
Dual TLR2 and TLR7 agonists as HIV latency-reversing agents.
Macedo AB, Novis CL, De Assis CM, Sorensen ES, Moszczynski P, Huang SH, Ren Y, Spivak AM, Jones RB, Planelles V, Bosque A. Macedo AB, et al. JCI Insight. 2018 Oct 4;3(19):e122673. doi: 10.1172/jci.insight.122673. JCI Insight. 2018. PMID: 30282829 Free PMC article.
12 results