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Photobac derived from bacteriochlorophyll-a shows potential for treating brain tumor in animal models by photodynamic therapy with desired pharmacokinetics and limited toxicity in rats and dogs.
Biomed Pharmacother. 2023 Dec;168:115731. doi: 10.1016/j.biopha.2023.115731. Epub 2023 Oct 17.
Biomed Pharmacother. 2023.
PMID: 37857248
Free PMC article.
Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer.
Patel N, Pera P, Joshi P, Dukh M, Tabaczynski WA, Siters KE, Kryman M, Cheruku RR, Durrani F, Missert JR, Watson R, Ohulchanskyy TY, Tracy EC, Baumann H, Pandey RK.
Patel N, et al.
J Med Chem. 2016 Nov 10;59(21):9774-9787. doi: 10.1021/acs.jmedchem.6b00890. Epub 2016 Oct 31.
J Med Chem. 2016.
PMID: 27749069
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