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The human gut bacterial genotoxin colibactin alkylates DNA.
Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP. Wilson MR, et al. Science. 2019 Feb 15;363(6428):eaar7785. doi: 10.1126/science.aar7785. Science. 2019. PMID: 30765538 Free PMC article.
A small molecule inhibitor prevents gut bacterial genotoxin production.
Volpe MR, Velilla JA, Daniel-Ivad M, Yao JJ, Stornetta A, Villalta PW, Huang HC, Bachovchin DA, Balbo S, Gaudet R, Balskus EP. Volpe MR, et al. Nat Chem Biol. 2023 Feb;19(2):159-167. doi: 10.1038/s41589-022-01147-8. Epub 2022 Oct 17. Nat Chem Biol. 2023. PMID: 36253549 Free PMC article.
Development of a DNA Adductome Mass Spectral Database.
Guo J, Turesky RJ, Tarifa A, DeCaprio AP, Cooke MS, Walmsley SJ, Villalta PW. Guo J, et al. Chem Res Toxicol. 2020 Apr 20;33(4):852-854. doi: 10.1021/acs.chemrestox.0c00031. Epub 2020 Mar 30. Chem Res Toxicol. 2020. PMID: 32223224 Free PMC article.
41 results