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Page 1
Chemical probes for methyl lysine reader domains.
James LI, Frye SV. James LI, et al. Curr Opin Chem Biol. 2016 Aug;33:135-41. doi: 10.1016/j.cbpa.2016.06.004. Epub 2016 Jun 25. Curr Opin Chem Biol. 2016. PMID: 27348158 Free PMC article. Review.
Epigenetics: Tools and Technologies.
Janzen WP, Wigle TJ, Jin J, Frye SV. Janzen WP, et al. Drug Discov Today Technol. 2010 Spring;7(1):e59-e65. doi: 10.1016/j.ddtec.2010.07.004. Drug Discov Today Technol. 2010. PMID: 21243036 Free PMC article.
Small-molecule ligands of methyl-lysine binding proteins.
Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV. Herold JM, et al. J Med Chem. 2011 Apr 14;54(7):2504-11. doi: 10.1021/jm200045v. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417280 Free PMC article.
Competence and natural transformation in vibrios.
Sun Y, Bernardy EE, Hammer BK, Miyashiro T. Sun Y, et al. Mol Microbiol. 2013 Aug;89(4):583-95. doi: 10.1111/mmi.12307. Epub 2013 Jul 15. Mol Microbiol. 2013. PMID: 23803158 Free PMC article.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. Vedadi M, et al. Nat Chem Biol. 2011 Jul 10;7(8):566-74. doi: 10.1038/nchembio.599. Nat Chem Biol. 2011. PMID: 21743462 Free PMC article.
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57. doi: 10.1021/jm100478y. J Med Chem. 2010. PMID: 20614940 Free PMC article.
17 results