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Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. Nature. 2021. PMID: 33473210 Free PMC article.
Aging disrupts circadian gene regulation and function in macrophages.
Blacher E, Tsai C, Litichevskiy L, Shipony Z, Iweka CA, Schneider KM, Chuluun B, Heller HC, Menon V, Thaiss CA, Andreasson KI. Blacher E, et al. Nat Immunol. 2022 Feb;23(2):229-236. doi: 10.1038/s41590-021-01083-0. Epub 2021 Dec 23. Nat Immunol. 2022. PMID: 34949832 Free PMC article.
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.
Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Nat Immunol. 2019 Jan;20(1):50-63. doi: 10.1038/s41590-018-0255-3. Epub 2018 Nov 26. Nat Immunol. 2019. PMID: 30478397 Free PMC article.
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Lin GL, et al. Sci Transl Med. 2019 Nov 20;11(519):eaaw0064. doi: 10.1126/scitranslmed.aaw0064. Sci Transl Med. 2019. PMID: 31748226 Free PMC article.
Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
Wilson E, Umans J, Swarovski M, Minhas P, Midttun Ø, Ulvik AA, Shahid-Besanti M, Linortner P, Mhatre S, Wang Q, Channappa D, Corso N, Tian L, Fredericks C, Kerchner G, Plowey E, Cholerton B, Ueland P, Zabetian C, Gray N, Quinn J, Montine T, Sha S, Longo F, Wolk D, Chen-Plotkin A, Henderson V, Wyss-Coray T, Wagner A, Mormino E, Aghaeepour N, Poston K, Andreasson K. Wilson E, et al. Res Sq [Preprint]. 2024 Sep 26:rs.3.rs-4980210. doi: 10.21203/rs.3.rs-4980210/v1. Res Sq. 2024. PMID: 39399688 Free PMC article. Preprint.