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RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB. Gudiño V, et al. Nat Commun. 2021 Apr 20;12(1):2335. doi: 10.1038/s41467-021-22531-3. Nat Commun. 2021. PMID: 33879799 Free PMC article.
Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1.
Dunbar K, Valanciute A, Lima ACS, Vinuela PF, Jamieson T, Rajasekaran V, Blackmur J, Ochocka-Fox AM, Guazzelli A, Cammareri P, Arends MJ, Sansom OJ, Myant KB, Farrington SM, Dunlop MG, Din FVN. Dunbar K, et al. Cell Mol Gastroenterol Hepatol. 2021;11(2):465-489. doi: 10.1016/j.jcmgh.2020.09.010. Epub 2020 Sep 22. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32971322 Free PMC article.
Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial.
Joharatnam-Hogan N, Cafferty F, Hubner R, Swinson D, Sothi S, Gupta K, Falk S, Patel K, Warner N, Kunene V, Rowley S, Khabra K, Underwood T, Jankowski J, Bridgewater J, Crossley A, Henson V, Berkman L, Gilbert D, Kynaston H, Ring A, Cameron D, Din F, Graham J, Iveson T, Adams R, Thomas A, Wilson R, Pramesh CS, Langley R; Add-Aspirin Trial Management Group. Joharatnam-Hogan N, et al. Lancet Gastroenterol Hepatol. 2019 Nov;4(11):854-862. doi: 10.1016/S2468-1253(19)30289-4. Epub 2019 Aug 30. Lancet Gastroenterol Hepatol. 2019. PMID: 31477558 Free article. Clinical Trial.
Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation.
Blackmur JP, Vaughan-Shaw PG, Donnelly K, Harris BT, Svinti V, Ochocka-Fox AM, Freile P, Walker M, Gurran T, Reid S, Semple CA, Din FVN, Timofeeva M, Dunlop MG, Farrington SM. Blackmur JP, et al. Front Genet. 2022 Jan 4;12:783970. doi: 10.3389/fgene.2021.783970. eCollection 2021. Front Genet. 2022. PMID: 35096006 Free PMC article.
Urgent improvements needed to diagnose and manage Lynch syndrome.
Monahan KJ, Alsina D, Bach S, Buchanan J, Burn J, Clark S, Dawson P, De Souza B, Din FV, Dolwani S, Dunlop MG, East J, Evans DG, Fearnhead N, Frayling IM, Glynne-Jones R, Hill J, Houlston R, Hull M, Lalloo F, Latchford A, Lishman S, Quirke P, Rees C, Rutter M, Sasieni P, Senapati A, Speake D, Thomas H, Tomlinson I. Monahan KJ, et al. BMJ. 2017 Mar 20;356:j1388. doi: 10.1136/bmj.j1388. BMJ. 2017. PMID: 28320700 Free article. No abstract available.
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