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Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: 10.1073/pnas.1215450109. Epub 2012 Oct 2. Proc Natl Acad Sci U S A. 2012. PMID: 23033494 Free PMC article.
PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.
MacKenzie KF, Clark K, Naqvi S, McGuire VA, Nöehren G, Kristariyanto Y, van den Bosch M, Mudaliar M, McCarthy PC, Pattison MJ, Pedrioli PG, Barton GJ, Toth R, Prescott A, Arthur JS. MacKenzie KF, et al. J Immunol. 2013 Jan 15;190(2):565-77. doi: 10.4049/jimmunol.1202462. Epub 2012 Dec 14. J Immunol. 2013. PMID: 23241891 Free PMC article.
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. Greenblatt MB, et al. J Clin Invest. 2010 Jul;120(7):2457-73. doi: 10.1172/JCI42285. Epub 2010 Jun 14. J Clin Invest. 2010. PMID: 20551513 Free PMC article.