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Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.
Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM. Hewitson JP, et al. PLoS Pathog. 2015 Mar 27;11(3):e1004676. doi: 10.1371/journal.ppat.1004676. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25816012 Free PMC article.
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