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Page 1
Genetic risk converges on regulatory networks mediating early type 2 diabetes.
Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE; HPAP Consortium; Parker SCJ, Powers AC, Brissova M. Walker JT, et al. Nature. 2023 Dec;624(7992):621-629. doi: 10.1038/s41586-023-06693-2. Epub 2023 Dec 4. Nature. 2023. PMID: 38049589 Free PMC article.
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes.
Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium; Faryabi RB, Naji A, Kaestner KH, Vahedi G. Fasolino M, et al. Nat Metab. 2022 Feb;4(2):284-299. doi: 10.1038/s42255-022-00531-x. Epub 2022 Feb 28. Nat Metab. 2022. PMID: 35228745 Free PMC article.
Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.
Knebel UE, Peleg S, Dai C, Cohen-Fultheim R, Jonsson S, Poznyak K, Israeli M, Zamashanski L, Glaser B, Levanon EY, Powers AC, Klochendler A, Dor Y. Knebel UE, et al. Cell Metab. 2024 Jan 2;36(1):48-61.e6. doi: 10.1016/j.cmet.2023.11.011. Epub 2023 Dec 20. Cell Metab. 2024. PMID: 38128529 Free PMC article.
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes.
Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. Rubio-Navarro A, et al. Nat Cell Biol. 2023 Apr;25(4):565-578. doi: 10.1038/s41556-023-01103-1. Epub 2023 Mar 16. Nat Cell Biol. 2023. PMID: 36928765 Free PMC article.
The human α cell in health and disease.
Pettway YD, Saunders DC, Brissova M. Pettway YD, et al. J Endocrinol. 2023 Jun 19;258(1):e220298. doi: 10.1530/JOE-22-0298. Print 2023 Jul 1. J Endocrinol. 2023. PMID: 37114672 Free PMC article. Review.
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.
Zhao Z, D'Oliveira Albanus R, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker SC, Chen S. Zhao Z, et al. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3343318. doi: 10.21203/rs.3.rs-3343318/v1. Res Sq. 2023. PMID: 37886586 Free PMC article. Preprint.
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