ZIA BC006161/ImNIH/Intramural NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2009	1
2016	2
2017	2
2018	1
2019	2
2020	3
2021	1
2022	2
2024	0

1

Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5.

Saha S, Yang X, Huang SN, Agama K, Baechler SA, Sun Y, Zhang H, Saha LK, Su S, Jenkins LM, Wang W, Pommier Y. Saha S, et al. Cell Rep. 2022 Jul 12;40(2):111067. doi: 10.1016/j.celrep.2022.111067. Cell Rep. 2022. PMID: 35830799 Free PMC article.

2

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.

Coussy F, El-Botty R, Château-Joubert S, Dahmani A, Montaudon E, Leboucher S, Morisset L, Painsec P, Sourd L, Huguet L, Nemati F, Servely JL, Larcher T, Vacher S, Briaux A, Reyes C, La Rosa P, Lucotte G, Popova T, Foidart P, Sounni NE, Noel A, Decaudin D, Fuhrmann L, Salomon A, Reyal F, Mueller C, Ter Brugge P, Jonkers J, Poupon MF, Stern MH, Bièche I, Pommier Y, Marangoni E. Coussy F, et al. Sci Transl Med. 2020 Feb 19;12(531):eaax2625. doi: 10.1126/scitranslmed.aax2625. Sci Transl Med. 2020. PMID: 32075943 Free PMC article.

3

Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.

Tang WL, Zhang Y, Hu DX, Yang H, Yu Q, Chen JW, Agama K, Pommier Y, An LK. Tang WL, et al. Eur J Med Chem. 2019 Sep 15;178:81-92. doi: 10.1016/j.ejmech.2019.05.074. Epub 2019 May 30. Eur J Med Chem. 2019. PMID: 31176097 Free PMC article.

4

Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance.

Aurrière J, Goudenege D, Baechler SA, Huang SN, Gueguen N, Desquiret-Dumas V, Chabrun F, Perrot R, Chevrollier A, Charif M, Baris OR, Pommier Y, Lenaers G, Khiati S. Aurrière J, et al. Mitochondrion. 2022 May;64:19-26. doi: 10.1016/j.mito.2022.02.005. Epub 2022 Feb 18. Mitochondrion. 2022. PMID: 35189384 Free PMC article.

5

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.

Elbadawi MM, Eldehna WM, Wang W, Agama KK, Pommier Y, Abe M. Elbadawi MM, et al. Eur J Med Chem. 2021 Apr 5;215:113261. doi: 10.1016/j.ejmech.2021.113261. Epub 2021 Feb 9. Eur J Med Chem. 2021. PMID: 33631697 Free PMC article.

6

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

Kankanala J, Marchand C, Abdelmalak M, Aihara H, Pommier Y, Wang Z. Kankanala J, et al. J Med Chem. 2016 Mar 24;59(6):2734-46. doi: 10.1021/acs.jmedchem.5b01973. Epub 2016 Mar 7. J Med Chem. 2016. PMID: 26910725 Free PMC article.

7

Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.

Elsayed MSA, Su Y, Wang P, Sethi T, Agama K, Ravji A, Redon CE, Kiselev E, Horzmann KA, Freeman JL, Pommier Y, Cushman M. Elsayed MSA, et al. J Med Chem. 2017 Jul 13;60(13):5364-5376. doi: 10.1021/acs.jmedchem.6b01870. Epub 2017 Jun 28. J Med Chem. 2017. PMID: 28657311 Free PMC article.

8

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.

Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G, Gromak N, Sordet O. Cristini A, et al. Cell Rep. 2019 Sep 17;28(12):3167-3181.e6. doi: 10.1016/j.celrep.2019.08.041. Cell Rep. 2019. PMID: 31533039 Free PMC article.

9

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).

Wang P, Elsayed MSA, Plescia CB, Ravji A, Redon CE, Kiselev E, Marchand C, Zeleznik O, Agama K, Pommier Y, Cushman M. Wang P, et al. J Med Chem. 2017 Apr 27;60(8):3275-3288. doi: 10.1021/acs.jmedchem.6b01565. Epub 2017 Apr 18. J Med Chem. 2017. PMID: 28418653 Free PMC article.

10

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.

Schmidt KT, Huitema ADR, Dorlo TPC, Peer CJ, Cordes LM, Sciuto L, Wroblewski S, Pommier Y, Madan RA, Thomas A, Figg WD. Schmidt KT, et al. Cancer Chemother Pharmacol. 2020 Oct;86(4):475-486. doi: 10.1007/s00280-020-04134-9. Epub 2020 Sep 8. Cancer Chemother Pharmacol. 2020. PMID: 32897402 Free PMC article. Clinical Trial.

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