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Page 1
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA. Asher WB, et al. Cell. 2022 May 12;185(10):1661-1675.e16. doi: 10.1016/j.cell.2022.03.042. Epub 2022 Apr 27. Cell. 2022. PMID: 35483373 Free PMC article.
The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias.
Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. bioRxiv [Preprint]. 2023 Nov 15:2023.11.10.566672. doi: 10.1101/2023.11.10.566672. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2024 Feb 21;15(4):854-867. doi: 10.1021/acschemneuro.3c00750. PMID: 38014284 Free PMC article. Updated. Preprint.
Dopamine receptor divergence revealed using a common ligand.
Sibley DR, Nilson AN, Moritz AE, Shi L. Sibley DR, et al. Trends Pharmacol Sci. 2023 Oct;44(10):637-639. doi: 10.1016/j.tips.2023.08.002. Epub 2023 Aug 19. Trends Pharmacol Sci. 2023. PMID: 37599183 Free PMC article.
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.
Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR. Klein Herenbrink C, et al. ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5. ACS Chem Biol. 2019. PMID: 31339684 Free PMC article.
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
Chambers DR, Sulima A, Luo D, Prisinzano TE, Goldberg A, Xie B, Shi L, Paronis CA, Bergman J, Nassehi N, Selley DE, Imler GH, Jacobson AE, Rice KC. Chambers DR, et al. Molecules. 2022 Sep 30;27(19):6455. doi: 10.3390/molecules27196455. Molecules. 2022. PMID: 36234992 Free PMC article.
31 results