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The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function.
Zhang J, Pandey M, Awe A, Lue N, Kittock C, Fikse E, Degner K, Staples J, Mokhasi N, Chen W, Yang Y, Adikaram P, Jacob N, Greenfest-Allen E, Thomas R, Bomeny L, Zhang Y, Petros TJ, Wang X, Li Y, Simonds WF. Zhang J, et al. Am J Hum Genet. 2024 Mar 7;111(3):473-486. doi: 10.1016/j.ajhg.2024.01.005. Epub 2024 Feb 13. Am J Hum Genet. 2024. PMID: 38354736 Free PMC article.
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.
Pandey M, Zhang JH, Adikaram PR, Kittock C, Lue N, Awe A, Degner K, Jacob N, Staples J, Thomas R, Kohnen AB, Ganesan S, Kabat J, Chen CK, Simonds WF. Pandey M, et al. JCI Insight. 2023 Jul 10;8(13):e134685. doi: 10.1172/jci.insight.134685. JCI Insight. 2023. PMID: 37219953 Free PMC article.