Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging.
Timmers PRHJ, Tiys ES, Sakaue S, Akiyama M, Kiiskinen TTJ, Zhou W, Hwang SJ, Yao C; Biobank Japan Project; FinnGen; Deelen J, Levy D, Ganna A, Kamatani Y, Okada Y, Joshi PK, Wilson JF, Tsepilov YA.
Timmers PRHJ, et al.
Nat Aging. 2022 Jan;2(1):19-30. doi: 10.1038/s43587-021-00159-8. Epub 2022 Jan 20.
Nat Aging. 2022.
PMID: 37118362
In the present study, we combine six European-ancestry genome-wide association studies of human aging traits-healthspan, father and mother lifespan, exceptional longevity, frailty index and self-rated health-in a principal component framework that maximizes their shared ge …
In the present study, we combine six European-ancestry genome-wide association studies of human aging traits-healthspan, father and mother l …