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Year Number of Results
1945 10
1946 53
1947 79
1948 63
1949 53
1950 1
1954 1
1955 5
1956 6
1957 1
1958 7
1959 2
1960 1
1961 2
1962 1
1963 6
1964 8
1965 9
1966 6
1967 7
1968 7
1969 18
1970 15
1971 25
1972 22
1973 26
1974 45
1975 106
1976 105
1977 135
1978 176
1979 206
1980 203
1981 260
1982 289
1983 355
1984 398
1985 483
1986 574
1987 638
1988 739
1989 836
1990 898
1991 974
1992 1158
1993 1242
1994 1355
1995 1572
1996 1713
1997 1826
1998 2045
1999 2275
2000 2487
2001 2631
2002 2937
2003 3111
2004 3604
2005 4066
2006 4302
2007 4745
2008 5059
2009 5543
2010 6273
2011 6867
2012 7782
2013 8256
2014 9186
2015 9875
2016 10082
2017 10503
2018 11171
2019 12216
2020 13807
2021 14954
2022 15068
2023 14518
2024 12543
2025 12

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201,302 results

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Page 1
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L. Sun X, et al. Cell Metab. 2023 Sep 5;35(9):1563-1579.e8. doi: 10.1016/j.cmet.2023.07.005. Epub 2023 Aug 4. Cell Metab. 2023. PMID: 37543034 Free article.
Here, we establish a multifarious role for SMC4 in the switching of colorectal cancer cells to a diapause-like state. SMC4 attenuation promotes the expression of three investment phase glycolysis enzymes increasing lactate production while also suppressing PGAM1. .. …
Here, we establish a multifarious role for SMC4 in the switching of colorectal cancer cells to a diapause-like state. SMC4 att …
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W. Chen S, et al. Nat Commun. 2022 Mar 10;13(1):1248. doi: 10.1038/s41467-022-28913-5. Nat Commun. 2022. PMID: 35273176 Free PMC article.
Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum (F. nucleatum) induces a dramatic decline of m(6)A modifications in CRC cells an …
Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms re …
The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression.
Tang J, Wang S, Weng M, Guo Q, Ren L, He Y, Cui Z, Cong M, Qin M, Yu J, Su R, Li X. Tang J, et al. Cancer Res. 2023 Nov 1;83(21):3593-3610. doi: 10.1158/0008-5472.CAN-23-0557. Cancer Res. 2023. PMID: 37560971
In this study, we identified increased translational efficiency (TE) as a hallmark of colorectal cancer by evaluating the transcriptomic and proteomic features of patients with colorectal cancer, along with comparative transcriptomic and ribosome-prote …
In this study, we identified increased translational efficiency (TE) as a hallmark of colorectal cancer by evaluating the tran …
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Toshimitsu K, et al. Nat Chem Biol. 2022 Jun;18(6):605-614. doi: 10.1038/s41589-022-00984-x. Epub 2022 Mar 10. Nat Chem Biol. 2022. PMID: 35273398
To gain insights into the pharmacobiology of human colorectal cancer (CRC), we here created a robust drug screening platform for patient-derived colorectal organoids. ...
To gain insights into the pharmacobiology of human colorectal cancer (CRC), we here created a robust drug screening platform f …
Association between gut microbiota and gastrointestinal cancer: a two-sample bi-directional Mendelian randomization study.
Su Q, Jin C, Bo Z, Yang Y, Wang J, Wang J, Zhou J, Chen Y, Zeng H, Chen G, Wang Y. Su Q, et al. Front Microbiol. 2023 Jul 18;14:1181328. doi: 10.3389/fmicb.2023.1181328. eCollection 2023. Front Microbiol. 2023. PMID: 37533836 Free PMC article.
Reverse MR analyses indicated that GI cancer was associated with 17 microbial taxa in all three MR methods, among them, a strong inverse association between colorectal cancer and family Clostridiaceae1 (OR: 0.91, 95% CI: 0.86-0.96, p = 0.001) was identified by Bonfe …
Reverse MR analyses indicated that GI cancer was associated with 17 microbial taxa in all three MR methods, among them, a strong inverse ass …
Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer.
Mukamel RE, Handsaker RE, Sherman MA, Barton AR, Hujoel MLA, McCarroll SA, Loh PR. Mukamel RE, et al. Cell. 2023 Aug 17;186(17):3659-3673.e23. doi: 10.1016/j.cell.2023.07.002. Epub 2023 Jul 31. Cell. 2023. PMID: 37527660 Free PMC article.
Non-coding VNTRs at TMCO1 and EIF3H appeared to generate the largest known contributions of common human genetic variation to risk of glaucoma and colorectal cancer, respectively. Each of these two VNTRs associated with a >2-fold range of risk across individuals. …
Non-coding VNTRs at TMCO1 and EIF3H appeared to generate the largest known contributions of common human genetic variation to risk of glauco …
Inflammatory Bowel Disease.
McDowell C, Farooq U, Haseeb M. McDowell C, et al. 2023 Aug 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Aug 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29262182 Free Books & Documents.
Both disorders have a genetic predisposition; neither is curable, and they both carry enormous morbidity. Finally, both increase the risk of colorectal cancer....
Both disorders have a genetic predisposition; neither is curable, and they both carry enormous morbidity. Finally, both increase the risk of …
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.
Liu H, Li D, Sun L, Qin H, Fan A, Meng L, Graves-Deal R, Glass SE, Franklin JL, Liu Q, Wang J, Yeatman TJ, Guo H, Zong H, Jin S, Chen Z, Deng T, Fang Y, Li C, Karijolich J, Patton JG, Wang X, Nie Y, Fan D, Coffey RJ, Zhao X, Lu Y. Liu H, et al. Mol Cancer. 2022 Mar 12;21(1):74. doi: 10.1186/s12943-022-01555-3. Mol Cancer. 2022. PMID: 35279145 Free PMC article.
We previously showed that miR-100 and miR-125b, embedded within the third intron of the ncRNA host gene MIR100HG, confer resistance to cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, in colorectal cancer (CRC). However, whether the MI …
We previously showed that miR-100 and miR-125b, embedded within the third intron of the ncRNA host gene MIR100HG, confer resistance to cetux …
201,302 results
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