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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.
Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ; Accelerating Medicines Partnership (AMP) RA/SLE Network; Rao DA, Kim EY, Brenner MB. Simmons DP, et al. Sci Immunol. 2022 Feb 11;7(68):eabf2846. doi: 10.1126/sciimmunol.abf2846. Epub 2022 Feb 11. Sci Immunol. 2022. PMID: 35148199 Free PMC article.
PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.
Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA; Accelerating Medicines Partnership (AMP) RA/SLE Network. Bocharnikov AV, et al. JCI Insight. 2019 Oct 17;4(20):e130062. doi: 10.1172/jci.insight.130062. JCI Insight. 2019. PMID: 31536480 Free PMC article.
High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.
Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B, Davidson A, Fine DM, Monroy-Trujillo J, Atta MG, DeJager W, Guthridge JM, Haag K, Rao DA, Brenner MB, Lederer JA, Apruzzese W, Belmont HM, Izmirly PM, Zaminski D, Wu M, Connery S, Payan-Schober F, Furie R, Dall'Era M, Cho K, Kamen D, Kalunian K, Anolik J, Barnas J, Ishimori M, Weisman MH; Accelerating Medicines Partnership (AMP) RA/SLE Network; Buyon JP, Petri M. Carlucci PM, et al. Rheumatology (Oxford). 2022 Nov 2;61(11):4335-4343. doi: 10.1093/rheumatology/keac067. Rheumatology (Oxford). 2022. PMID: 35212719 Free PMC article.