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A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections.
Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Kuppermann N, et al. JAMA Pediatr. 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. JAMA Pediatr. 2019. PMID: 30776077 Free PMC article.
IMPORTANCE: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. ...Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may …
IMPORTANCE: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and …
Radiographic pneumonia in young febrile infants presenting to the emergency department: secondary analysis of a prospective cohort study.
Florin TA, Ramilo O, Banks RK, Schnadower D, Quayle KS, Powell EC, Pickett ML, Nigrovic LE, Mistry R, Leetch AN, Hickey RW, Glissmeyer EW, Dayan PS, Cruz AT, Cohen DM, Bogie A, Balamuth F, Atabaki SM, VanBuren JM, Mahajan P, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Florin TA, et al. Emerg Med J. 2023 Dec 22;41(1):13-19. doi: 10.1136/emermed-2023-213089. Emerg Med J. 2023. PMID: 37770118
Respiratory syncytial virus was the predominant pathogen in the pneumonia groups and rhinovirus in infants without pneumonias. CONCLUSIONS: Radiographic pneumonias were uncommon in febrile infants. ...Although ANC and PCT levels were elevated in infants …
Respiratory syncytial virus was the predominant pathogen in the pneumonia groups and rhinovirus in infants without pneumonias. CONCLU …
The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants.
Nigrovic LE, Mahajan PV, Blumberg SM, Browne LR, Linakis JG, Ruddy RM, Bennett JE, Rogers AJ, Tzimenatos L, Powell EC, Alpern ER, Casper TC, Ramilo O, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Nigrovic LE, et al. Pediatrics. 2017 Jul;140(1):e20170695. doi: 10.1542/peds.2017-0695. Epub 2017 Jun 6. Pediatrics. 2017. PMID: 28759413 Free PMC article.
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants 60 days of age with and without serious bacterial infections (SBIs). METHODS: We performed a planned secondary analysis o …
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile …
Practice Variation in the Evaluation and Disposition of Febrile Infants 60 Days of Age.
Rogers AJ, Kuppermann N, Anders J, Roosevelt G, Hoyle JD Jr, Ruddy RM, Bennett JE, Borgialli DA, Dayan PS, Powell EC, Casper TC, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Rogers AJ, et al. J Emerg Med. 2019 Jun;56(6):583-591. doi: 10.1016/j.jemermed.2019.03.003. Epub 2019 Apr 20. J Emerg Med. 2019. PMID: 31014970 Free PMC article.
BACKGROUND: Febrile infants commonly present to emergency departments for evaluation. OBJECTIVE: We describe the variation in diagnostic testing and hospitalization of febrile infants 60 days of age presenting to the emergency departments in the Pediat …
BACKGROUND: Febrile infants commonly present to emergency departments for evaluation. OBJECTIVE: We describe the variation in …
Leukopenia, neutropenia, and procalcitonin levels in young febrile infants with invasive bacterial infections.
Krack AT, Eckerle M, Mahajan P, Ramilo O, VanBuren JM, Banks RK, Casper TC, Schnadower D, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Krack AT, et al. Acad Emerg Med. 2024 Sep;31(9):903-914. doi: 10.1111/acem.14921. Epub 2024 Apr 25. Acad Emerg Med. 2024. PMID: 38661246
BACKGROUND AND OBJECTIVE: Serum procalcitonin (PCT) is a highly accurate biomarker for stratifying the risk of invasive bacterial infections (IBIs) in febrile infants 60 days old. However, PCT is unavailable in some settings. We explored the association of leukopeni …
BACKGROUND AND OBJECTIVE: Serum procalcitonin (PCT) is a highly accurate biomarker for stratifying the risk of invasive bacterial infections …
Epidemiology of Bacteremia in Febrile Infants Aged 60 Days and Younger.
Powell EC, Mahajan PV, Roosevelt G, Hoyle JD Jr, Gattu R, Cruz AT, Rogers AJ, Atabaki SM, Jaffe DM, Casper TC, Ramilo O, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Powell EC, et al. Ann Emerg Med. 2018 Feb;71(2):211-216. doi: 10.1016/j.annemergmed.2017.07.488. Epub 2017 Oct 6. Ann Emerg Med. 2018. PMID: 28988964 Free PMC article.
STUDY OBJECTIVE: To describe the current epidemiology of bacteremia in febrile infants 60 days of age and younger in the Pediatric Emergency Care Applied Research Network (PECARN). ...CONCLUSION: The prevalence of bacteremia and meningitis among febrile in …
STUDY OBJECTIVE: To describe the current epidemiology of bacteremia in febrile infants 60 days of age and younger in the Pedia …
Risk of Bacterial Coinfections in Febrile Infants 60 Days Old and Younger with Documented Viral Infections.
Mahajan P, Browne LR, Levine DA, Cohen DM, Gattu R, Linakis JG, Anders J, Borgialli D, Vitale M, Dayan PS, Casper TC, Ramilo O, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Mahajan P, et al. J Pediatr. 2018 Dec;203:86-91.e2. doi: 10.1016/j.jpeds.2018.07.073. Epub 2018 Sep 6. J Pediatr. 2018. PMID: 30195552 Free PMC article.
OBJECTIVE: To determine the risk of serious bacterial infections (SBIs) in young febrile infants with and without viral infections. STUDY DESIGN: Planned secondary analyses of a prospective observational study of febrile infants 60 days of age or young …
OBJECTIVE: To determine the risk of serious bacterial infections (SBIs) in young febrile infants with and without viral infect …
Radiographic Pneumonia in Febrile Infants 60 Days and Younger.
Florin TA, Ramilo O, Hoyle JD Jr, Jaffe DM, Tzimenatos L, Atabaki SM, Cohen DM, VanBuren JM, Mahajan P, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Florin TA, et al. Pediatr Emerg Care. 2021 May 1;37(5):e221-e226. doi: 10.1097/PEC.0000000000002187. Pediatr Emerg Care. 2021. PMID: 32701869 Free PMC article.
OBJECTIVE: Few prospective studies have assessed the occurrence of radiographic pneumonia in young febrile infants. We analyzed factors associated with radiographic pneumonias in febrile infants 60 days or younger evaluated in pediatric emergency depar …
OBJECTIVE: Few prospective studies have assessed the occurrence of radiographic pneumonia in young febrile infants. We analyze …