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Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.
Li SC, Higgins GC, Chen M, Torok KS, Rabinovich CE, Stewart K, Laxer RM, Pope E, Haines KA, Punaro M, O'Neil KM; Childhood Arthritis and Rheumatology Research Alliance Localized Scleroderma Clinical and Ultrasound Study group. Li SC, et al. Rheumatology (Oxford). 2021 Dec 1;60(12):5724-5733. doi: 10.1093/rheumatology/keab238. Rheumatology (Oxford). 2021. PMID: 33711155
The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma outcome measures.
Arkachaisri T, Vilaiyuk S, Li S, O'Neil KM, Pope E, Higgins GC, Punaro M, Rabinovich EC, Rosenkranz M, Kietz DA, Rosen P, Spalding SJ, Hennon TR, Torok KS, Cassidy E, Medsger TA Jr; Localized Scleroderma Clinical and Ultrasound Study Group. Arkachaisri T, et al. J Rheumatol. 2009 Dec;36(12):2819-29. doi: 10.3899/jrheum.081284. Epub 2009 Oct 15. J Rheumatol. 2009. PMID: 19833758 Free PMC article.