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Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial.
Bloos F, Rüddel H, Thomas-Rüddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Gründling M, Marshall J, Simon P, Levy MM, Weiss M, Weyland A, Gerlach H, Schürholz T, Engel C, Matthäus-Krämer C, Scheer C, Bach F, Riessen R, Poidinger B, Dey K, Weiler N, Meier-Hellmann A, Häberle HH, Wöbker G, Kaisers UX, Reinhart K; MEDUSA study group. Bloos F, et al. Intensive Care Med. 2017 Nov;43(11):1602-1612. doi: 10.1007/s00134-017-4782-4. Epub 2017 May 2. Intensive Care Med. 2017. PMID: 28466151 Clinical Trial.
A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis.
Schwarzkopf D, Matthaeus-Kraemer CT, Thomas-Rüddel DO, Rüddel H, Poidinger B, Bach F, Gerlach H, Gründling M, Lindner M, Scheer C, Simon P, Weiss M, Reinhart K, Bloos F; MEDUSA study group. Schwarzkopf D, et al. Sci Rep. 2022 Mar 10;12(1):3925. doi: 10.1038/s41598-022-07915-9. Sci Rep. 2022. PMID: 35273276 Free PMC article.
Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature.
Thomas-Rüddel DO, Hoffmann P, Schwarzkopf D, Scheer C, Bach F, Komann M, Gerlach H, Weiss M, Lindner M, Rüddel H, Simon P, Kuhn SO, Wetzker R, Bauer M, Reinhart K, Bloos F; MEDUSA study group. Thomas-Rüddel DO, et al. Crit Care. 2021 Oct 21;25(1):368. doi: 10.1186/s13054-021-03776-2. Crit Care. 2021. PMID: 34674733 Free PMC article. Clinical Trial.
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial.
Rüddel H, Thomas-Rüddel DO, Reinhart K, Bach F, Gerlach H, Lindner M, Marshall JC, Simon P, Weiss M, Bloos F, Schwarzkopf D; MEDUSA study group. Rüddel H, et al. Crit Care. 2022 Feb 28;26(1):51. doi: 10.1186/s13054-022-03901-9. Crit Care. 2022. PMID: 35227308 Free PMC article. Clinical Trial.
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study.
Bloos F, Thomas-Rüddel D, Rüddel H, Engel C, Schwarzkopf D, Marshall JC, Harbarth S, Simon P, Riessen R, Keh D, Dey K, Weiß M, Toussaint S, Schädler D, Weyland A, Ragaller M, Schwarzkopf K, Eiche J, Kuhnle G, Hoyer H, Hartog C, Kaisers U, Reinhart K; MEDUSA Study Group. Bloos F, et al. Crit Care. 2014 Mar 3;18(2):R42. doi: 10.1186/cc13755. Crit Care. 2014. PMID: 24589043 Free PMC article.