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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population.
Maglalang PD, Sinha J, Zimmerman K, McCann S, Edginton A, Hornik CP, Hornik CD, Muller WJ, Al-Uzri A, Meyer M, Chen JY, Anand R, Perrin EM, Gonzalez D; Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee. Maglalang PD, et al. Clin Pharmacokinet. 2024 Jun;63(6):885-899. doi: 10.1007/s40262-024-01367-2. Epub 2024 May 30. Clin Pharmacokinet. 2024. PMID: 38814425
Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity.
Wen J, McCann S, Balevic SJ, Muller WJ, Hornik CD, Autmizguine J, Anderson SG, Payne EH, Turdalieva S, Gonzalez D; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Wen J, et al. J Clin Pharmacol. 2024 Dec;64(12):1491-1504. doi: 10.1002/jcph.6108. Epub 2024 Aug 9. J Clin Pharmacol. 2024. PMID: 39120865
Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population.
Thompson EJ, Jeong A, Helfer VE, Shakhnovich V, Edginton A, Balevic SJ, James LP, Collier DN, Anand R, Gonzalez D; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Thompson EJ, et al. CPT Pharmacometrics Syst Pharmacol. 2024 Aug;13(8):1394-1408. doi: 10.1002/psp4.13167. Epub 2024 Jun 4. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38837864 Free PMC article. Clinical Trial.