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Perturbation and resilience of the gut microbiome up to 3 months after β-lactams exposure in healthy volunteers suggest an important role of microbial β-lactamases.
d'Humières C, Delavy M, Alla L, Ichou F, Gauliard E, Ghozlane A, Levenez F, Galleron N, Quinquis B, Pons N, Mullaert J, Bridier-Nahmias A, Condamine B, Touchon M, Rainteau D, Lamazière A, Lesnik P, Ponnaiah M, Lhomme M, Sertour N, Devente S, Docquier JD, Bougnoux ME, Tenaillon O, Magnan M, Ruppé E, Grall N, Duval X, Ehrlich D, Mentré F, Denamur E, Rocha EPC, Le Chatelier E, Burdet C; PrediRes study group. d'Humières C, et al. Microbiome. 2024 Mar 12;12(1):50. doi: 10.1186/s40168-023-01746-0. Microbiome. 2024. PMID: 38468305 Free PMC article.
A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics.
Delavy M, Burdet C, Sertour N, Devente S, Docquier JD, Grall N, Volant S, Ghozlane A, Duval X, Mentré F, d'Enfert C, Bougnoux ME; PrediRes Study Group. Delavy M, et al. mBio. 2022 Dec 20;13(6):e0288022. doi: 10.1128/mbio.02880-22. Epub 2022 Nov 30. mBio. 2022. PMID: 36448778 Free PMC article.