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Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study.
Oberbauer R, Kreis H, Johnson RW, Mota A, Claesson K, Ruiz JC, Wilczek H, Jamieson N, Henriques AC, Paczek L, Chapman J, Burke JT; Rapamune Maintenance Regimen Study Group. Oberbauer R, et al. Transplantation. 2003 Jul 27;76(2):364-70. doi: 10.1097/01.TP.0000074360.62032.39. Transplantation. 2003. PMID: 12883194 Clinical Trial.
Health-related quality-of-life outcomes of sirolimus-treated kidney transplant patients after elimination of cyclosporine A: results of a 2-year randomized clinical trial.
Oberbauer R, Hutchison B, Eris J, Arias M, Claesson K, Mota A, Kreis H, Kleinman L, Wang F, Chen J, Revicki DA; Rapamune Maintenance Regimen Study Group. Oberbauer R, et al. Transplantation. 2003 Apr 27;75(8):1277-85. doi: 10.1097/01.TP.0000061766.37366.6B. Transplantation. 2003. PMID: 12717216 Clinical Trial.
Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal function.
Russ G, Segoloni G, Oberbauer R, Legendre C, Mota A, Eris J, Grinyó JM, Friend P, Lawen J, Hartmann A, Schena FP, Lelong M, Burke JT, Neylan JF; Rapamune Maintenance Regimen Study Group. Russ G, et al. Transplantation. 2005 Nov 15;80(9):1204-11. doi: 10.1097/01.tp.0000178393.78084.9b. Transplantation. 2005. PMID: 16314787 Clinical Trial.
Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation.
Oberbauer R, Segoloni G, Campistol JM, Kreis H, Mota A, Lawen J, Russ G, Grinyó JM, Stallone G, Hartmann A, Pinto JR, Chapman J, Burke JT, Brault Y, Neylan JF; Rapamune Maintenance Regimen Study Group. Oberbauer R, et al. Transpl Int. 2005 Jan;18(1):22-8. doi: 10.1111/j.1432-2277.2004.00052.x. Transpl Int. 2005. PMID: 15612979 Free article. Clinical Trial.
Factors influencing glomerular filtration rate in renal transplantation after cyclosporine withdrawal using sirolimus-based therapy: a multivariate analysis of results at five years.
Legendre C, Brault Y, Morales JM, Oberbauer R, Altieri P, Riad H, Mahony J, Messina M, Pussell B, Martínez JG, Lelong M, Burke JT, Neylan JF; Rapamune Maintenance Regimen Study Group. Legendre C, et al. Clin Transplant. 2007 May-Jun;21(3):330-6. doi: 10.1111/j.1399-0012.2007.00645.x. Clin Transplant. 2007. PMID: 17488381 Clinical Trial.
Similar lipid profile but improved long-term outcomes with sirolimus after cyclosporine withdrawal compared to sirolimus with continuous cyclosporine.
Morales JM, Hartmann A, Walker R, Arns W, Senatorski G, Grinyó JM, Shoker A, Wilczek H, Jamieson NV, Lelong M, Brault Y, Burke JT, Scarola JA; Rapamune Maintenance Regimen Study Group. Morales JM, et al. Transplant Proc. 2009 Jul-Aug;41(6):2339-44. doi: 10.1016/j.transproceed.2009.05.009. Transplant Proc. 2009. PMID: 19715914