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Page 1
Showing results for sites ap
Search for Sitjes AP instead (1 results)
The AP-1 transcriptional complex: Local switch or remote command?
Bejjani F, Evanno E, Zibara K, Piechaczyk M, Jariel-Encontre I. Bejjani F, et al. Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):11-23. doi: 10.1016/j.bbcan.2019.04.003. Epub 2019 Apr 26. Biochim Biophys Acta Rev Cancer. 2019. PMID: 31034924 Review.
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all cellular and physiological functions. ...If these studies confirm that AP-1 can sometimes act as a local transcriptional switch operating in the vicinity of transcription star …
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all cellular and physiological functions. ...I …
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites.
Khodyreva S, Lavrik O. Khodyreva S, et al. DNA Repair (Amst). 2020 Jun;90:102847. doi: 10.1016/j.dnarep.2020.102847. Epub 2020 May 5. DNA Repair (Amst). 2020. PMID: 32492598 Review.
Apurinic/apyrimidinic (AP) sites are widespread lesions in genomic DNA, arising from a number of exogenous and endogenous sources. ...It is important to note that the aldehyde at the deoxyribose C1 atom both in intact and cleaved AP sites can readily r …
Apurinic/apyrimidinic (AP) sites are widespread lesions in genomic DNA, arising from a number of exogenous and endogenous sour …
AP-Seq: A Method to Measure Apurinic Sites and Small Base Adducts Genome-Wide.
Poetsch AR. Poetsch AR. Methods Mol Biol. 2020;2175:95-108. doi: 10.1007/978-1-0716-0763-3_8. Methods Mol Biol. 2020. PMID: 32681486
DNA is constantly challenged by chemical modification and spontaneous loss of its bases, which results in apurinic sites (AP-sites). In addition to the direct route, modified bases may be converted into AP-sites through enzymatic removal of the …
DNA is constantly challenged by chemical modification and spontaneous loss of its bases, which results in apurinic sites (AP- …
AP sites in various mRNA positions cross-link to the protein uS3 in the translating mammalian ribosome.
Ochkasova AS, Meschaninova MI, Venyaminova AG, Graifer DM, Karpova GG. Ochkasova AS, et al. Biochim Biophys Acta Proteins Proteom. 2021 Oct;1869(10):140698. doi: 10.1016/j.bbapap.2021.140698. Epub 2021 Jul 14. Biochim Biophys Acta Proteins Proteom. 2021. PMID: 34273599
Abasic (AP) sites in mRNAs are lesions whose accumulation in cells is linked to various neurodegenerative diseases arising from the appearance of truncated peptides due to the premature cessation of translation of these mRNAs. ...An analysis of 80S ribosomal complex …
Abasic (AP) sites in mRNAs are lesions whose accumulation in cells is linked to various neurodegenerative diseases arising fro …
Formation, detection and repair of AP sites.
Talpaert-Borlé M. Talpaert-Borlé M. Mutat Res. 1987 Nov;181(1):45-56. doi: 10.1016/0027-5107(87)90286-7. Mutat Res. 1987. PMID: 2444877 Review.
A new method for the measurement of AP sites based on their reaction with [14C]methoxyamine is described. It has been applied to the measurement of AP sites produced in DNA either by physical (gamma-rays) or chemical (methyl methanesulphonate, osmium t …
A new method for the measurement of AP sites based on their reaction with [14C]methoxyamine is described. It has been applied …
Complementary Functions of Plant AP Endonucleases and AP Lyases during DNA Repair of Abasic Sites Arising from C:G Base Pairs.
Jordano-Raya M, Beltrán-Melero C, Moreno-Recio MD, Martínez-Macías MI, Ariza RR, Roldán-Arjona T, Córdoba-Cañero D. Jordano-Raya M, et al. Int J Mol Sci. 2021 Aug 16;22(16):8763. doi: 10.3390/ijms22168763. Int J Mol Sci. 2021. PMID: 34445469 Free PMC article.
AP sites opposite G are common intermediates during the repair of deaminated cytosines, whereas AP sites opposite C frequently arise from oxidized guanines. We found that the major Arabidopsis AP endonuclease (ARP) exhibited a higher efficiency …
AP sites opposite G are common intermediates during the repair of deaminated cytosines, whereas AP sites opposit …
Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method.
Cai Y, Cao H, Wang F, Zhang Y, Kapranov P. Cai Y, et al. Nat Commun. 2022 Oct 5;13(1):5868. doi: 10.1038/s41467-022-33594-1. Nat Commun. 2022. PMID: 36198706 Free PMC article.
Here, we present the development and validation of SSiNGLe-AP method, which can map a common type of DNA damage, abasic (AP) sites, in a genome-wide and high-resolution manner. We apply this method to six different tissues of mice with different ages and huma …
Here, we present the development and validation of SSiNGLe-AP method, which can map a common type of DNA damage, abasic (AP) …
AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.
Nilsen L, Forstrøm RJ, Bjørås M, Alseth I. Nilsen L, et al. Nucleic Acids Res. 2012 Mar;40(5):2000-9. doi: 10.1093/nar/gkr933. Epub 2011 Nov 13. Nucleic Acids Res. 2012. PMID: 22084197 Free PMC article.
AP sites are both mutagenic and cytotoxic and key enzymes for their removal are AP endonucleases. However, AP endonuclease independent repair initiated by DNA glycosylases performing beta,delta-elimination cleavage of the AP sites has bee …
AP sites are both mutagenic and cytotoxic and key enzymes for their removal are AP endonucleases. However, AP en …
Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight.
Zhang SY, Bruce K, Danaei Z, Li RJW, Barros DR, Kuah R, Lim YM, Mariani LH, Cherney DZ, Chiu JFM, Reich HN, Lam TKT. Zhang SY, et al. Cell Metab. 2023 May 2;35(5):875-886.e5. doi: 10.1016/j.cmet.2023.03.014. Epub 2023 Apr 14. Cell Metab. 2023. PMID: 37060902 Free article.
Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes (T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans, but the mechanistic site(s) of action remain elusive. Metformin increases plasma growth/d …
Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes (T2D), lowers plasma glucose levels, food intake, an …
Nonenzymatic release of N7-methylguanine channels repair of abasic sites into an AP endonuclease-independent pathway in Arabidopsis.
Barbado C, Córdoba-Cañero D, Ariza RR, Roldán-Arjona T. Barbado C, et al. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E916-E924. doi: 10.1073/pnas.1719497115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339505 Free PMC article.
Abasic (apurinic/apyrimidinic, AP) sites in DNA arise from spontaneous base loss or by enzymatic removal during base excision repair. ...We provide here genetic and biochemical evidence that, in Arabidopsis, AP sites generated by spontaneous loss of N7 …
Abasic (apurinic/apyrimidinic, AP) sites in DNA arise from spontaneous base loss or by enzymatic removal during base excision …
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