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Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV.
Stirrup OT, Sabin CA, Phillips AN, Williams I, Churchill D, Tostevin A, Hill T, Dunn DT; UK HIV Drug Resistance Database and the UK Collaborative HIV Cohort. Stirrup OT, et al. J Virus Erad. 2019 Nov 4;5(4):204-211. doi: 10.1016/S2055-6640(20)30037-6. J Virus Erad. 2019. PMID: 31754443 Free PMC article.
OBJECTIVES: The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral therapy and risk of virological failure (VF) with or without drug resistance. METHODS: We conducted an analysis of UK …
OBJECTIVES: The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line …
Continuation of emtricitabine/lamivudine within combination antiretroviral therapy following detection of the M184V/I HIV-1 resistance mutation.
Stirrup OT, Asboe D, Pozniak A, Sabin CA, Gilson R, Mackie NE, Tostevin A, Hill T, Dunn DT; UK HIV Drug Resistance Database and the UK Collaborative HIV Cohort. Stirrup OT, et al. HIV Med. 2020 May;21(5):309-321. doi: 10.1111/hiv.12829. Epub 2020 Jan 11. HIV Med. 2020. PMID: 31927793 Free PMC article.
METHODS: We identified people with viruses harbouring the M184V/I mutation in UK multicentre data sets who had treatment change/initiation within 1 year. We analysed outcomes of viral suppression (< 200 HIV-1 RNA copies/mL) and appearance of new major drug resistance mu …
METHODS: We identified people with viruses harbouring the M184V/I mutation in UK multicentre data sets who had treatment change/initi …
An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs.
Smit E, White E, Clark D, Churchill D, Zhang H, Collins S, Pillay D, Sabin C, Nelson M, Winston A, Jose S, Tostevin A, Dunn DT; UK HIV Drug Resistance Database and the UK Collaborative HIV Cohort. Smit E, et al. J Antimicrob Chemother. 2017 Jul 1;72(7):2075-2082. doi: 10.1093/jac/dkx091. J Antimicrob Chemother. 2017. PMID: 28379449 Free PMC article.
We exploited the diversity of viral subtypes within the UK to undertake a direct comparative analysis. PATIENTS AND METHODS: We analysed only sequences with major IAS-defined mutations from patients with virological failure. ...
We exploited the diversity of viral subtypes within the UK to undertake a direct comparative analysis. PATIENTS AND METHODS: We analy …