About
Entrepreneur leading a paradigm shift in drug discovery. Studied rumor propagation across…
Activity
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Powerful innovations in #Biotech are helping breathe new life into people, products, and the planet. Ordaos Bio's work is featured in Deloitte's new…
Powerful innovations in #Biotech are helping breathe new life into people, products, and the planet. Ordaos Bio's work is featured in Deloitte's new…
Shared by David Longo
Experience
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Education
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Harvard University
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BIOS E-40 (Proteomics), BIOS E-16 (Cell Biology), BIOS E-12 (Molecular Biology), BIOS E-10 (Biochemistry), STAT E-150 (Intermediate Statistics), BIOS E-45 (Genomics), BIOS S-129 (Stem Cell and Regenerative Biology), ENSC S-135 (Biochemical Engineering), CSCI E-39 (Modular Design Patterns/React), BIOT E-120 (Ethics and Biotrends), MGMT E-5420 (Entrepreneurship ans Innovation)
Wrote a review of current brown adipose tissue research.
Programming Languages Used: JavaScript, React…BIOS E-40 (Proteomics), BIOS E-16 (Cell Biology), BIOS E-12 (Molecular Biology), BIOS E-10 (Biochemistry), STAT E-150 (Intermediate Statistics), BIOS E-45 (Genomics), BIOS S-129 (Stem Cell and Regenerative Biology), ENSC S-135 (Biochemical Engineering), CSCI E-39 (Modular Design Patterns/React), BIOT E-120 (Ethics and Biotrends), MGMT E-5420 (Entrepreneurship ans Innovation)
Wrote a review of current brown adipose tissue research.
Programming Languages Used: JavaScript, React, NodeJS, VHDL -
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CS224N (Deep NLP), CS224U (Natural Language Understanding), CS236 (Deep Generative Models), CS221 (Artificial Intelligence), CS110 (Computer Systems), CS107 (Computer Organization), BIOMEDIN210 (Modeling Biomedical Systems)
- Developed an expert system that crawled PubMed's entire Open Access Subset and answered queries using a Knowledge Graph
- Developed a generative model for molecule generation -
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Entrepreneur Development Program with Bill Aulet, Trish Cotter, Kit Hickey, Dipul Patel, Mike Volpe, Erin Scott, Kirk Arnold, Matthew Rhodes-Kropf, Jeff Fagnan, Ed Roberts, and Jorge Cortell
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Advanced Machine Learning for Big Data and Text Processing
Machine Learning for Healthcare
Advances in Imaging and Machine Learning: Medical, VR-AR, and Self-Driving Cars
Deep Learning for AI and Computer Vision -
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Activities and Societies: Robotics Club, Eight Beat Measure A Cappella, RIT Student Music Association
Dean’s List 2005-2006
Outstanding Undergraduate Researcher for work with Dr. Bernard P Brooks, Dr. David Ross, and Dr. Nicholas DiFonzo progressing the field of social network analysis and rumor propagation. Built a large scale rumor propagation simulation across scale-free networks using C++, QT, and Boost.
Worked with Java, Lisp, Scheme, C, C++.
Minors in Economics, Finance, Music & Technology -
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Summer Session, Summer 2006
Public Speaking, Matrix Algebra, Theory of Probability, Intermediate Microeconomics -
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Activities and Societies: Rowed crew on the Thames
Summer Session, Summer 2003
US/UK Relations, British Debate -
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Activities and Societies: Rowed crew on the Potomac
Summer Session, Summer 2002
American Spy Operations of the 20th Century, Intro to Macroeconomics -
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Activities and Societies: Science Olympiads, Computer Club, Jazz Band, Marching Band, Highlands Voices (Honor Choir), Theater
Won Science Olympiads Regional Competitions
Took Marching Band State Championships
President, Computer Club
Allendale Woman’s Club Computer Science Technology Award
Named "Most likely to be the next Bill Gates" in the school yearbook -
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Travelled to Beijing, Shanghai, Suzhou, and Tibet to experience Chinese culture, observe how multinational corporations worked within the Chinese systems, learn the art of Guanxi, and a pick up a bit of Mandarin along the way.
(Why yes, I did in fact pass out immediately upon stepping out of the plane in Tibet and had to be put on an oxygen pillow.)
Licenses & Certifications
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Professional Certificate In Machine Learning & Artificial Intelligence
MIT Professional Education
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Volunteer Experience
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Product Manager
The Contemporary A Cappella Society
- 7 years 1 month
Arts and Culture
I helped to develop educational music festivals around the county.
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College of Science National Council Member
Rochester Institute of Technology
- Present 1 year 10 months
Education
The RIT College of Science National Council comprises a talented group of individuals called upon regularly to advise the Dean on strategic issues and initiatives of major significance to the College.
Publications
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Deep Learning Based Protein Therapeutics Design to Treat HER2+ Cancers
AACR
The Ordaos Design Engine, a deep learning-based end-to-end protein therapeutics design platform, was developed and used to create de novo mini-proteins to target HER2. Candidate proteins are evaluated in silico for binding affinity and specificity, secondary and tertiary structure, isoelectric point, solubility, and other drug-like properties, and iteratively improved to achieve multi-objective optimization. These in silico designed binders can be produced with high yield and purity using…
The Ordaos Design Engine, a deep learning-based end-to-end protein therapeutics design platform, was developed and used to create de novo mini-proteins to target HER2. Candidate proteins are evaluated in silico for binding affinity and specificity, secondary and tertiary structure, isoelectric point, solubility, and other drug-like properties, and iteratively improved to achieve multi-objective optimization. These in silico designed binders can be produced with high yield and purity using mammalian protein expression systems, and have been shown to bind to human HER2 with EC50 in the nanomolar range by ELISA.
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So You Want To Sing A Cappella
Rowman & Littlefield
See publicationContributed pages to Chapter 17 – Behind the Scenes
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Modeling the RIT Facebook Social Network
RITHink
See publicationExamines the structure of the RIT Facebook network, sub-network discovery (with applications to terrorism), and rumor and virus propagation dynamics.
Projects
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4th Conference on Mathematical Methods in Counterterrorism
See projectPresented a model for locating terrorist cells using Big Data to national security representatives.
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International Scholar Laureate Program on Technology
Travelled across China and Tibet surveying local culture, manufacturing practices, and innovation centers.
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(Poster Session) AskMD - a Knowledge System
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Presented poster representing results of a probabilistic knowledge graph-based expert system generated from NLP on 1.5 million PubMed Open Access Subsystem articles.
Honors & Awards
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Over 200 Contemporary A Cappella Recording Awards
Contemporary A Cappella Society
Engineered the technical, cultural, and emotional inputs to win over 200 awards in “the Grammys of A Cappella”
One of less than ten people to achieve this lifetime total. -
Mix with the Masters: Michael Brauer
Mix with the Masters
Selected as one of fifteen from all over the world to study with Michael Brauer, producer of artists such as Aretha Franklin, Luther Vandross, John Mayer, and Coldplay. Seminar took place in the south of France at the famous Studio La Fabrique.
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Outstanding Undergraduate Research Scholar
Rochester Institute of Technology
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Dean’s List
Rochester Institute of Technology
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