Researchers worldwide have been looking forward to using novel ways to purify fresh water contain... more Researchers worldwide have been looking forward to using novel ways to purify fresh water containing pollutants and disease vectors.
Introduction Despite the paucity of scientific evidence, CAM is widely used for the prevention an... more Introduction Despite the paucity of scientific evidence, CAM is widely used for the prevention and treatment of illness among patients with chronic kidney disease, including end-stage renal disease and kidney transplant recipients. It is evident that the irrational use of CAM among CKD patients and its non-disclosure to healthcare providers could lead to adverse drug events. Hence, the current study was conducted to evaluate the prevalence, types, and non-disclosure of CAM use among CKD patients and kidney transplant recipients in Saudi Arabia. Methods A cross-sectional study was conducted on 170 CKD patients (121 with stages 3 and 4, two with stage 5 and on hemodialysis, and 47 kidney transplant recipients). Face-to-face questionnaire-based interviews were conducted employing a convenience sampling technique. The study outcomes were the prevalence of CAM, types of CAM use, monthly expenditure on CAM, the source of information about CAM, and CAM disclosure to healthcare providers. A...
The major challenge in skin tissue engineering is the creation of physically and functionally sui... more The major challenge in skin tissue engineering is the creation of physically and functionally suitable extracellular matrix (ECM) scaffolds. A manuka honey-treated polyvinyl pyrrolidine (Mh@PVP) composite was successfully electrospun to produce nanofibrous scaffold that aids in the rapid growth of ECM and serves as a vehicle for drug delivery. Different characterizations namely SEM, XRD, and FTIR were utilized to elucidate the fabricated electrospun nanofibrous scaffolds (ENS). By increasing the concentration of manuka honey (Mh) in the formula, the mechanical, tensile, and conductivity properties of the polyvinyl pyrrolidine (PVP) solutions were significantly improved. As the concentration of honey rose, the width and direction of the ENS produced altered. For wound healing, honey’s ability to heal wounds faster may be boosted by a higher PVP concentration, which makes honey more easily incorporated. Because of its burst-and-continuous methylglyoxal release patterns, which may last...
The spread of many infectious diseases by vectors is a globally severe issue. Climate change and ... more The spread of many infectious diseases by vectors is a globally severe issue. Climate change and the increase of vector resistance are the primary sources of rising mosquito populations. Therefore, advanced approaches are needed to prevent the dispersal of life-threatening diseases. Herein, Mn2O3 NPs and MnCoO nanocomposites were presented as mosquitocidal agents. The synthesized samples were prepared by a co-precipitation route and characterized using different techniques indicating the change of host Mn2O3 structure to 2D MnCoO nanoflakes with Co3+ integration. The thermal decomposition of the nanoparticles was examined by TGA analysis, showing high stability. The energy gap (Eg) of Mn2O3 was estimated within the visible spectrum of the value 2.95 eV, which reduced to 2.80 eV with doping support. The impact of Mn2O3 and MnCoO on immature stages was investigated by semithin photomicrographs exhibiting significant changes in the midgut, fat tissue and muscles of the third larval ins...
Herein, we report the synthesis of spinel cobalt oxide nanorods (Co3O4 NRs) by a modified co-prec... more Herein, we report the synthesis of spinel cobalt oxide nanorods (Co3O4 NRs) by a modified co-precipitation approach and examine their larvicidal activity against Culex pipiens. The structure and morphology of the as-prepared Co3O4 NRs were emphasized using X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDAX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). It was found that Co3O4 nanostructures have a face-centered spinel cubic crystal structure with a mean crystallite size of 38 nm. These nanostructures have a rod like shape with a mean diameter of 30 nm and an average length of 60 nm. The TGA measurements revealed the high stability of the formed spinel cubic structure at 400 °C. The optical behavior indicates the direct transition of electrons through an optical band gap in the range of 2.92–3.08 eV. These unique chemical and physical properties of Co3O4 NRs enabled them to be employed as a strong agent for killi...
Background: Unconjugated hyperbilirubinemia is one of the most common conditions in neonates. Con... more Background: Unconjugated hyperbilirubinemia is one of the most common conditions in neonates. Conventional treatment are phototherapy and exchange transfusion. Phototherapy is safe and effective, but it has several disadvantages. That indicates the need to develop an alternative pharmacological treatment strategies. It should be less invasive, and at least, as effective and safe as phototherapy. The present study was designed to investigate the effects of Silybum marianum (silymarin) on the duration of phototherapy, which is known to have antioxidant, anti-inflammatory, hepatic protective, regenerative and enhancing glucoronidation activities. Patients and methods: A randomized double-blind clinical trial was conducted in170 full term healthy neonates with UCB in two well-matched groups. 85 received oral 0.75mg/kg of Silymarin twice daily plus phototherapy and 85 neonates received placebo and phototherapy. Total serum bilirubin (TSB) was measured every 24h, SGPT and SGOT level were ...
This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare... more This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare CAM practice with different demographic and disease characteristics of the participants. A cross-sectional study was conducted among CD patients. During the three-months of data collection period, a total of 377 patients were approached and 208 patients participated in the study, giving a response rate of 55.17%. A p value of <0.05 was considered as significant. Among the study population, 94 (45.2%) patients were CAM users. Diabetes mellitus patients were the majority (48 (51.06%)) followed by hypertensive patients (34 (36.17%)). Spiritual therapies were the most common CAM followed by herbal products. Among CAM users, 41 (19.7%) patients reported disclosing CAM use to their health care providers. Among all the sociodemographic variables, gender (p = 0.029), marital status (p = 0.034) and education level (p = 0.047) were significantly associated with CAM use. In conclusion, the use ...
Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventio... more Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventional treatment consists of phototherapy and exchange transfusion. Phototherapy is safe and effective but it has several disadvantages. Exchange transfusion is associated with a significant morbidity and even mortality. That indicates the need to develop an alternative pharmacological treatment strategies. It should be less invasive and at least as effective and safe as phototherapy. Herbal therapy has recently received special attention. Silymarin herbal drug has laxative, antioxidant, anti-inflammatory, hepatic protective, regenerative and enhancing of glucoronidation activities. The study presented here aimed to investigate effect of Silymarin on duration of phototherapy. A prospective cohort trial performed on 170 full term healthy neonates with UCB, 85 received oral 3.75mg/kg of Silymarin twice daily plus phototherapy and 85 neonates received only phototherapy. Total serum bilirubin (...
International Journal of Environmental Research and Public Health, 2021
Background: A pragmatic shift in the healthcare sector characterized by moving from curative to p... more Background: A pragmatic shift in the healthcare sector characterized by moving from curative to preventive approaches highlights the role of pharmacovigilance in patient safety. There have been few published studies on patient reporting of adverse drug reactions (ADRs) in Saudi Arabia. This qualitative study aims to explore the community opinions and the need for patient-friendly smartphone applications (SPAs) to enhance their participation in ADR reporting. Methods: Purposeful sampling was followed to recruit study participants, a semi-structured interview guide was used to conduct interviews, and the saturation was reached after the 13th interviewer; no new information was obtained after two subsequent interviews. All the interviews were audio-recorded, transcribed verbatim, and analyzed by means of a standard content analysis framework. Results: As per the WHO guidelines, eleven participants were aware of the term “ADR”. All the participants denied receiving any prior education a...
Back ground and aim of work Unconjugated hyperbilirubinemia (UCB) is one of the most common condi... more Back ground and aim of work Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventional treatments are phototherapy and exchange transfusion. Phototherapy is safe and effective, but it has several disadvantages, which indicates the need to develop alternative pharmacological treatment strategies. These alternative treatment strategies should be less invasive and at least as effective and safe as phototherapy. The present study was designed to investigate the effects of Silybum marianum (silymarin) on the duration of phototherapy, which is known to have antioxidant, anti-inflammatory, hepatic-protective, and regenerative properties, including enhancing glucuronidation activities. Patients and methods A randomized double-blind clinical trial was conducted on 170 full-term healthy neonates with UCB divided into two well-matched groups. Of the 170 neonates, 85 received 3.75 mg/kg of silymarin orally, twice daily, in addition to phototherapy, and 85 received placebo and phototherapy. Total serum bilirubin was measured every 24 h, and alanine aminotransferase (SGPT) and alanine transaminase (SGOT) levels were measured before and after therapy in both groups. Results The mean duration of phototherapy was found to be significantly reduced from 5.3±0.82 days in the control group to 4.2±0.76 days in the silymarin-treated group ( P =0.001). SGPT and SGOT levels were significantly normalized ( P =0.001). Conclusion Silymarin at a dose of 3.75 mg/kg twice daily along with phototherapy was more effective than phototherapy alone in treating full-term healthy neonates with UCB.
Treatment of brain diseases is always limited by the physiological nature of the highly selective... more Treatment of brain diseases is always limited by the physiological nature of the highly selective blood-brain barrier (BBB) and the electrostatic charge of the nanoporous extracellular matrix. Nanomedical application provides a promising drug delivery revolution for the treatment of neurodegenerative diseases (NDDs). It depends on improving the pharmacokinetic distribution of drugs through the central nervous system. Nanotechnology offers various forms of nanoparticles, and these nanoparticles have brain-targeted and long-acting properties with minimal systemic adverse effects and motor complications. Gene delivery vehicles and nanocarriers including neurotrophic factors are promising therapeutics for many NDDs, and they can modulate neuronal survival and synaptic connectivity. Neurotrophic factors when integrated with the nanotechnological approaches can pass the BBB merely, representing a significant challenging track. Clinical trials proved that levodopa nanoparticles cause littl...
Researchers worldwide have been looking forward to using novel ways to purify fresh water contain... more Researchers worldwide have been looking forward to using novel ways to purify fresh water containing pollutants and disease vectors.
Introduction Despite the paucity of scientific evidence, CAM is widely used for the prevention an... more Introduction Despite the paucity of scientific evidence, CAM is widely used for the prevention and treatment of illness among patients with chronic kidney disease, including end-stage renal disease and kidney transplant recipients. It is evident that the irrational use of CAM among CKD patients and its non-disclosure to healthcare providers could lead to adverse drug events. Hence, the current study was conducted to evaluate the prevalence, types, and non-disclosure of CAM use among CKD patients and kidney transplant recipients in Saudi Arabia. Methods A cross-sectional study was conducted on 170 CKD patients (121 with stages 3 and 4, two with stage 5 and on hemodialysis, and 47 kidney transplant recipients). Face-to-face questionnaire-based interviews were conducted employing a convenience sampling technique. The study outcomes were the prevalence of CAM, types of CAM use, monthly expenditure on CAM, the source of information about CAM, and CAM disclosure to healthcare providers. A...
The major challenge in skin tissue engineering is the creation of physically and functionally sui... more The major challenge in skin tissue engineering is the creation of physically and functionally suitable extracellular matrix (ECM) scaffolds. A manuka honey-treated polyvinyl pyrrolidine (Mh@PVP) composite was successfully electrospun to produce nanofibrous scaffold that aids in the rapid growth of ECM and serves as a vehicle for drug delivery. Different characterizations namely SEM, XRD, and FTIR were utilized to elucidate the fabricated electrospun nanofibrous scaffolds (ENS). By increasing the concentration of manuka honey (Mh) in the formula, the mechanical, tensile, and conductivity properties of the polyvinyl pyrrolidine (PVP) solutions were significantly improved. As the concentration of honey rose, the width and direction of the ENS produced altered. For wound healing, honey’s ability to heal wounds faster may be boosted by a higher PVP concentration, which makes honey more easily incorporated. Because of its burst-and-continuous methylglyoxal release patterns, which may last...
The spread of many infectious diseases by vectors is a globally severe issue. Climate change and ... more The spread of many infectious diseases by vectors is a globally severe issue. Climate change and the increase of vector resistance are the primary sources of rising mosquito populations. Therefore, advanced approaches are needed to prevent the dispersal of life-threatening diseases. Herein, Mn2O3 NPs and MnCoO nanocomposites were presented as mosquitocidal agents. The synthesized samples were prepared by a co-precipitation route and characterized using different techniques indicating the change of host Mn2O3 structure to 2D MnCoO nanoflakes with Co3+ integration. The thermal decomposition of the nanoparticles was examined by TGA analysis, showing high stability. The energy gap (Eg) of Mn2O3 was estimated within the visible spectrum of the value 2.95 eV, which reduced to 2.80 eV with doping support. The impact of Mn2O3 and MnCoO on immature stages was investigated by semithin photomicrographs exhibiting significant changes in the midgut, fat tissue and muscles of the third larval ins...
Herein, we report the synthesis of spinel cobalt oxide nanorods (Co3O4 NRs) by a modified co-prec... more Herein, we report the synthesis of spinel cobalt oxide nanorods (Co3O4 NRs) by a modified co-precipitation approach and examine their larvicidal activity against Culex pipiens. The structure and morphology of the as-prepared Co3O4 NRs were emphasized using X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDAX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). It was found that Co3O4 nanostructures have a face-centered spinel cubic crystal structure with a mean crystallite size of 38 nm. These nanostructures have a rod like shape with a mean diameter of 30 nm and an average length of 60 nm. The TGA measurements revealed the high stability of the formed spinel cubic structure at 400 °C. The optical behavior indicates the direct transition of electrons through an optical band gap in the range of 2.92–3.08 eV. These unique chemical and physical properties of Co3O4 NRs enabled them to be employed as a strong agent for killi...
Background: Unconjugated hyperbilirubinemia is one of the most common conditions in neonates. Con... more Background: Unconjugated hyperbilirubinemia is one of the most common conditions in neonates. Conventional treatment are phototherapy and exchange transfusion. Phototherapy is safe and effective, but it has several disadvantages. That indicates the need to develop an alternative pharmacological treatment strategies. It should be less invasive, and at least, as effective and safe as phototherapy. The present study was designed to investigate the effects of Silybum marianum (silymarin) on the duration of phototherapy, which is known to have antioxidant, anti-inflammatory, hepatic protective, regenerative and enhancing glucoronidation activities. Patients and methods: A randomized double-blind clinical trial was conducted in170 full term healthy neonates with UCB in two well-matched groups. 85 received oral 0.75mg/kg of Silymarin twice daily plus phototherapy and 85 neonates received placebo and phototherapy. Total serum bilirubin (TSB) was measured every 24h, SGPT and SGOT level were ...
This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare... more This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare CAM practice with different demographic and disease characteristics of the participants. A cross-sectional study was conducted among CD patients. During the three-months of data collection period, a total of 377 patients were approached and 208 patients participated in the study, giving a response rate of 55.17%. A p value of <0.05 was considered as significant. Among the study population, 94 (45.2%) patients were CAM users. Diabetes mellitus patients were the majority (48 (51.06%)) followed by hypertensive patients (34 (36.17%)). Spiritual therapies were the most common CAM followed by herbal products. Among CAM users, 41 (19.7%) patients reported disclosing CAM use to their health care providers. Among all the sociodemographic variables, gender (p = 0.029), marital status (p = 0.034) and education level (p = 0.047) were significantly associated with CAM use. In conclusion, the use ...
Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventio... more Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventional treatment consists of phototherapy and exchange transfusion. Phototherapy is safe and effective but it has several disadvantages. Exchange transfusion is associated with a significant morbidity and even mortality. That indicates the need to develop an alternative pharmacological treatment strategies. It should be less invasive and at least as effective and safe as phototherapy. Herbal therapy has recently received special attention. Silymarin herbal drug has laxative, antioxidant, anti-inflammatory, hepatic protective, regenerative and enhancing of glucoronidation activities. The study presented here aimed to investigate effect of Silymarin on duration of phototherapy. A prospective cohort trial performed on 170 full term healthy neonates with UCB, 85 received oral 3.75mg/kg of Silymarin twice daily plus phototherapy and 85 neonates received only phototherapy. Total serum bilirubin (...
International Journal of Environmental Research and Public Health, 2021
Background: A pragmatic shift in the healthcare sector characterized by moving from curative to p... more Background: A pragmatic shift in the healthcare sector characterized by moving from curative to preventive approaches highlights the role of pharmacovigilance in patient safety. There have been few published studies on patient reporting of adverse drug reactions (ADRs) in Saudi Arabia. This qualitative study aims to explore the community opinions and the need for patient-friendly smartphone applications (SPAs) to enhance their participation in ADR reporting. Methods: Purposeful sampling was followed to recruit study participants, a semi-structured interview guide was used to conduct interviews, and the saturation was reached after the 13th interviewer; no new information was obtained after two subsequent interviews. All the interviews were audio-recorded, transcribed verbatim, and analyzed by means of a standard content analysis framework. Results: As per the WHO guidelines, eleven participants were aware of the term “ADR”. All the participants denied receiving any prior education a...
Back ground and aim of work Unconjugated hyperbilirubinemia (UCB) is one of the most common condi... more Back ground and aim of work Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventional treatments are phototherapy and exchange transfusion. Phototherapy is safe and effective, but it has several disadvantages, which indicates the need to develop alternative pharmacological treatment strategies. These alternative treatment strategies should be less invasive and at least as effective and safe as phototherapy. The present study was designed to investigate the effects of Silybum marianum (silymarin) on the duration of phototherapy, which is known to have antioxidant, anti-inflammatory, hepatic-protective, and regenerative properties, including enhancing glucuronidation activities. Patients and methods A randomized double-blind clinical trial was conducted on 170 full-term healthy neonates with UCB divided into two well-matched groups. Of the 170 neonates, 85 received 3.75 mg/kg of silymarin orally, twice daily, in addition to phototherapy, and 85 received placebo and phototherapy. Total serum bilirubin was measured every 24 h, and alanine aminotransferase (SGPT) and alanine transaminase (SGOT) levels were measured before and after therapy in both groups. Results The mean duration of phototherapy was found to be significantly reduced from 5.3±0.82 days in the control group to 4.2±0.76 days in the silymarin-treated group ( P =0.001). SGPT and SGOT levels were significantly normalized ( P =0.001). Conclusion Silymarin at a dose of 3.75 mg/kg twice daily along with phototherapy was more effective than phototherapy alone in treating full-term healthy neonates with UCB.
Treatment of brain diseases is always limited by the physiological nature of the highly selective... more Treatment of brain diseases is always limited by the physiological nature of the highly selective blood-brain barrier (BBB) and the electrostatic charge of the nanoporous extracellular matrix. Nanomedical application provides a promising drug delivery revolution for the treatment of neurodegenerative diseases (NDDs). It depends on improving the pharmacokinetic distribution of drugs through the central nervous system. Nanotechnology offers various forms of nanoparticles, and these nanoparticles have brain-targeted and long-acting properties with minimal systemic adverse effects and motor complications. Gene delivery vehicles and nanocarriers including neurotrophic factors are promising therapeutics for many NDDs, and they can modulate neuronal survival and synaptic connectivity. Neurotrophic factors when integrated with the nanotechnological approaches can pass the BBB merely, representing a significant challenging track. Clinical trials proved that levodopa nanoparticles cause littl...
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Papers by Lamyaa Kassem