Abstract
Isoxazolinylacetamides bearing a phosphoramidate group alpha- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.
MeSH terms
-
Animals
-
Blood Platelets / chemistry
-
Calcium / pharmacology
-
Citric Acid / pharmacology
-
Dogs
-
Drug Design
-
Heparin / pharmacology
-
Humans
-
Inhibitory Concentration 50
-
Isoxazoles / administration & dosage
-
Isoxazoles / pharmacology*
-
Platelet Aggregation Inhibitors / pharmacology
-
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
-
Platelet Glycoprotein GPIIb-IIIa Complex / chemistry*
Substances
-
Isoxazoles
-
Platelet Aggregation Inhibitors
-
Platelet Glycoprotein GPIIb-IIIa Complex
-
Citric Acid
-
Heparin
-
Calcium