Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

Bioorg Med Chem Lett. 1999 Jan 18;9(2):151-6. doi: 10.1016/s0960-894x(98)00705-7.

Abstract

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobe nzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors / chemistry*
  • Cyclooxygenase Inhibitors / pharmacology
  • Humans
  • Indans / pharmacology
  • Inhibitory Concentration 50
  • Isoenzymes / chemistry*
  • Membrane Proteins
  • Microsomes / chemistry
  • Prostaglandin-Endoperoxide Synthases / chemistry*
  • Sulfonamides / chemistry
  • U937 Cells

Substances

  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Indans
  • Isoenzymes
  • L 745337
  • Membrane Proteins
  • Sulfonamides
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases
  • flosulide