Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications

F C Nelson; S J Stachel; C P Eng; S N Sehgal

doi:10.1016/s0960-894x(98)00735-5

Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications

Bioorg Med Chem Lett. 1999 Jan 18;9(2):295-300. doi: 10.1016/s0960-894x(98)00735-5.

Authors

F C Nelson¹, S J Stachel, C P Eng, S N Sehgal

Affiliation

¹ Wyeth-Ayerst Research, Pearl River, NY 10965, USA.

PMID: 10021948
DOI: 10.1016/s0960-894x(98)00735-5

Abstract

A novel series of rapamycin derivatives with modifications in the C(22)-C(27) region has been prepared. These compounds are evaluated for their ability to prevent ring fragmentation while still retaining immunosuppressive capabilities.

MeSH terms

Chromatography, High Pressure Liquid
Humans
Immunosuppressive Agents / chemistry
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Sirolimus / analogs & derivatives*
Sirolimus / chemistry*
Survival
Temperature

Substances

Immunosuppressive Agents
Sirolimus