[Problems of intravenous lidocaine treatment in status epilepticus or clustering seizures in childhood]

No To Hattatsu. 1999 Jan;31(1):14-20.
[Article in Japanese]

Abstract

Lidocaine was administered intravenously as a substitute for diazepam, to 12 patients with status epilepticus or clustering seizures aged 26 days to 11 years. The medication was very effective in 3 cases with acute convulsions, which disappeared immediately after infusion of lidocaine without relapse. The medication was effective only temporarily in 4 patients; they experienced relapsing seizures during drip infusion of lidocaine intravenously for maintenance. All the relapsing seizures were secondarily generalized ones with diffuse ictal discharges. In 2 cases of localization-related epilepsy, complex partial seizures evolved to secondarily generalized seizures immediately after administration of lidocaine. It must be noticed that in a relatively large number of cases lidocaine is ineffective or even harmful.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Anticonvulsants / administration & dosage*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infusions, Intravenous
  • Lidocaine / administration & dosage*
  • Male
  • Recurrence
  • Seizures / drug therapy*
  • Status Epilepticus / drug therapy*

Substances

  • Anticonvulsants
  • Lidocaine