Abstract
In the nervous system, glial cells greatly outnumber neurons but the full extent of their role in determining neural activity remains unknown. Here the axotactin (axo) gene of Drosophila was shown to encode a member of the neurexin protein superfamily secreted by glia and subsequently localized to axonal tracts. Null mutations of axo caused temperature-sensitive paralysis and a corresponding blockade of axonal conduction. Thus, the AXO protein appears to be a component of a glial-neuronal signaling mechanism that helps to determine the membrane electrical properties of target axons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Action Potentials
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Animals
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Axons / physiology*
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DNA, Complementary
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Drosophila / embryology
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Drosophila / genetics
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Drosophila / physiology*
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Embryo, Nonmammalian / physiology
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Gene Expression Regulation, Developmental
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Genes, Insect
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Insect Proteins / genetics
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Insect Proteins / physiology*
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Ion Channels / physiology
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Mutation
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Neuroglia / physiology*
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Neuromuscular Junction / physiology
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Signal Transduction*
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Synaptic Transmission
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Temperature
Substances
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DNA, Complementary
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Insect Proteins
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Ion Channels