Stretching lattice models of protein folding

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2031-5. doi: 10.1073/pnas.96.5.2031.

Abstract

A new class of experiments that probe folding of individual protein domains uses mechanical stretching to cause the transition. We show how stretching forces can be incorporated in lattice models of folding. For fast folding proteins, the analysis suggests a complex relation between the force dependence and the reaction coordinate for folding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Drug Stability
  • Kinetics
  • Models, Theoretical*
  • Molecular Sequence Data
  • Peptides / chemistry
  • Protein Denaturation
  • Protein Folding*

Substances

  • Peptides