Single-equivalent muscle models are often used to estimate loads on the lumbosacral joint after net extension moments have been calculated by means of inverse dynamics. These models usually ignore the effects trunk flexion has on the extensor lever arm. In addition, no systematic analysis of the sensitivity to the anatomical and functional assumptions made in these models is available. In the present study a series of single-equivalent models incorporating trunk flexion dependence was derived from a detailed description of the trunk musculature. Each model was based on different anatomical and functional assumptions. The differences of estimates of compression and shear forces on the lumbosacral disc during a lifting movement resulting from these models were analysed. The results show that these load estimates heavily depend on assumptions regarding anthropometry, lumbar curvature and coactivity of abdominal muscles and only moderately on assumptions regarding force sharing between extensor muscles. Fairly simple single-equivalent models with the net moment and thorax orientation as input can be used to predict lumbosacral compression and shear.