Abstract
Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen Presentation*
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Biological Transport
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Cysteine / metabolism
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Dendritic Cells
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Fibronectins / metabolism
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Immunoglobulin Fc Fragments / metabolism
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Immunohistochemistry
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Lectins, C-Type*
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Ligands
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Lymph Nodes / cytology
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Lymph Nodes / metabolism
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Macrophages / immunology*
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Macrophages / metabolism*
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Mannose Receptor
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Mannose-Binding Lectins*
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Mice
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Mice, Inbred BALB C
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Ovalbumin / immunology
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / metabolism*
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Recombinant Fusion Proteins / chemistry
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Recombinant Fusion Proteins / metabolism
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Spleen / cytology
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Spleen / metabolism
Substances
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Fibronectins
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Immunoglobulin Fc Fragments
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Lectins, C-Type
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Ligands
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Mannose Receptor
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Mannose-Binding Lectins
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Receptors, Cell Surface
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Recombinant Fusion Proteins
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Ovalbumin
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Cysteine